UniProt Q6DCU6
Sigma non-opioid intracellular receptor 1 (Q6DCU6)
Sigma non-opioid intracellular receptor 1 (UniProt Q6DCU6): 12 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 43 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q6DCU6
- Protein
- Sigma non-opioid intracellular receptor 1
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 43 · 6 records with a druggable one
Structures
13 records of Q6DCU6 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7W2B | The closed conformation of the sigma-1 receptor from xenopus laevis | x-ray diffraction | A, C, E, D, F, B, G, H, I, J, K, L | AU | — |
| 7W2C | The closed conformation of the sigma-1 receptor from xenopus laevis complexed with PRE084 | x-ray diffraction | A, C, E, B, D, F, G, H, I, J, K, L | AU, E84 | — |
| 7W2D | The closed conformation of the sigma-1 receptor from xenopus laevis complexed with S1RA | x-ray diffraction | A, C, E, B, D, F, G, H, I, J, K, L | AU, 88E | — |
| 7W2E | An open-like conformation of the sigma-1 receptor from xenopus laevis | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 7W2F | An open-like conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084 by… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | E84 | 20 (best 0.83) |
| 7W2F | An open-like conformation of the sigma-1 receptor from xenopus laevis complexed with PRE084 by… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | E84 | — |
| 7W2G | An open-like conformation of the sigma-1 receptor from xenopus laevis complexed with PRE084 by… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | E84 | — |
| 7W2H | A double cysteine variant of the sigma-1 receptor from xenopus laevis complexed with S1RA | x-ray diffraction | A, C, E, B, D, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | 88E | — |
| 8W4C | The sigma-1 receptor from Xenopus laevis in complex with progesterone by soaking | x-ray diffraction | A | STR | 1 (best 0.84) |
| 8W4D | Crystal structure of the sigma-1 receptor from Xenopus laevis in the absence of known ligands | x-ray diffraction | A | — | 1 (best 0.83) |
| 8WWB | The sigma-1 receptor from Xenopus laevis in complex with dehydroepiandrosterone sulfate by soaking… | x-ray diffraction | A | ZWY | 1 (best 0.83) |
| 8YBB | Crystal structure of the sigma-1 receptor from Xenopus laevis with side opening | x-ray diffraction | A, B, C, D, E, F | — | 19 (best 0.84) |
| Q6DCU6 | AlphaFold monomer V2.0 prediction for sigma non-opioid intracellular receptor 1 (Q6DCU6) | predicted | A | — | 1 (best 0.82) |
Ligands
Experiment against prediction
- 7W2H chain M against the predicted model Q6DCU6: TM-score 0.99, RMSD 0.54 Å
- 7W2D chain A against the predicted model Q6DCU6: TM-score 0.99, RMSD 0.66 Å
- 7W2H chain P against the predicted model Q6DCU6: TM-score 0.98, RMSD 0.74 Å
- 7W2C chain A against the predicted model Q6DCU6: TM-score 0.98, RMSD 0.77 Å
- 7W2B chain A against the predicted model Q6DCU6: TM-score 0.98, RMSD 0.80 Å
- 7W2H chain E against the predicted model Q6DCU6: TM-score 0.98, RMSD 0.93 Å
- 7W2F chain J against the predicted model Q6DCU6: TM-score 0.97, RMSD 0.96 Å
- 7W2B chain K against the predicted model Q6DCU6: TM-score 0.97, RMSD 0.99 Å
- 7W2B chain B against the predicted model Q6DCU6: TM-score 0.97, RMSD 1.06 Å
- 7W2H chain S against the predicted model Q6DCU6: TM-score 0.97, RMSD 1.08 Å
Elsewhere
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