UniProt Q6CIT4
Histone-lysine N-methyltransferase, H3 lysine-4 specific (Q6CIT4)
Histone-lysine N-methyltransferase, H3 lysine-4 specific (UniProt Q6CIT4), EC 2.1.1.43: 5 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 14 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q6CIT4
- Protein
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- EC
- 2.1.1.43
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 14 · 3 records with a druggable one
Structures
6 records of Q6CIT4 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6CHG | Crystal structure of the yeast COMPASS catalytic module | x-ray diffraction | C | SAM, ZN | 4 (best 0.80) |
| 6CHG | Crystal structure of the yeast compass catalytic module | x-ray diffraction | C | ZN | — |
| 6UGM | Structural basis of COMPASS eCM recognition of an unmodified nucleosome | electron microscopy | M | SAM, ZN | 5 (best 0.85) |
| 6UGM | Structural basis of compass ecm recognition of an unmodified nucleosome | electron microscopy | M | ZN | — |
| 6UH5 | Structural basis of compass ecm recognition of the H2BUB nucleosome | electron microscopy | M | ZN | — |
| Q6CIT4 | AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-4 specific… | predicted | A | — | 5 (best 0.68) |
Ligands
Experiment against prediction
- 6CHG chain C against the predicted model Q6CIT4: TM-score 0.94, RMSD 1.50 Å
- 6CHG chain C against the predicted model Q6CIT4: TM-score 0.93, RMSD 1.50 Å
- 6UH5 chain M against the predicted model Q6CIT4: TM-score 0.84, RMSD 2.26 Å
- 6UGM chain M against the predicted model Q6CIT4: TM-score 0.82, RMSD 2.32 Å
- 6UGM chain M against the predicted model Q6CIT4: TM-score 0.81, RMSD 2.32 Å
Elsewhere
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