UniProt Q5SJX7
Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase (Q5SJX7)
Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase (UniProt Q5SJX7), EC 6.1.1.11: 4 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 78 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q5SJX7
- Protein
- Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase
- EC
- 6.1.1.11
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 78 · 5 records with a druggable one
Structures
5 records of Q5SJX7 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8FCY | Engineered human dynein motor domain in microtubule-bound state | electron microscopy | A | ADP, ATP | 20 (best 0.81) |
| 8FD6 | Engineered human dynein motor domain in the microtubule-unbound state in the buffer containing… | electron microscopy | A | ATP, ADP, VO4, MG | 20 (best 0.84) |
| 8FDT | Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the… | electron microscopy | A | ATP, ADP, VO4 | 18 (best 0.84) |
| 8FDU | Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the… | electron microscopy | A | ADP | 17 (best 0.85) |
| Q5SJX7 | AlphaFold monomer V2.0 prediction for serine--tRNA ligase (Q5SJX7) | predicted | A | — | 3 (best 0.74) |
Ligands
Experiment against prediction
- 8FDT chain A against the predicted model Q5SJX7: TM-score 0.07, RMSD 6.91 Å
- 8FD6 chain A against the predicted model Q5SJX7: TM-score 0.07, RMSD 6.96 Å
- 8FCY chain A against the predicted model Q5SJX7: TM-score 0.07, RMSD 7.44 Å
- 8FDU chain A against the predicted model Q5SJX7: TM-score 0.16, RMSD 7.06 Å
Elsewhere
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