UniProt Q5JWF2
Engineered domain of human G alpha S long isoform (Q5JWF2)
Engineered domain of human G alpha S long isoform (UniProt Q5JWF2), EC 3.6.5.-: 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 58 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q5JWF2
- Protein
- Engineered domain of human G alpha S long isoform
- EC
- 3.6.5.-
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 58 · 8 records with a druggable one
Structures
11 records of Q5JWF2 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5G53 | Structure of the adenosine A2A receptor bound to an engineered G protein | x-ray diffraction | C, D | GDP | 5 (best 0.69) |
| 5G53 | Structure of the adenosine A2A receptor bound to an engineered G protein | x-ray diffraction | C, D | — | — |
| 6XOX | cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970 | electron microscopy | A | — | 10 (best 0.83) |
| 6XOX | Cryo-EM of human glp-1R bound to non-peptide agonist LY3502970 | electron microscopy | A | — | — |
| 8GY7 | Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein | electron microscopy | A | — | 10 (best 0.82) |
| 8I2G | FSHR-Follicle stimulating hormone-compound 716340-Gs complex | electron microscopy | A | — | 7 (best 0.83) |
| 8JHB | FZD6 Gs complex | electron microscopy | A | — | 8 (best 0.83) |
| 8ZH8 | Human GPR103 -Gq complex bound to QRFP26 | electron microscopy | A | — | 9 (best 0.82) |
| 9BKK | Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex | electron microscopy | A | — | 4 (best 0.82) |
| 9DQJ | CryoEM structure of Gq-coupled MRGPRD with a new agonist EP-3945 | electron microscopy | B | — | 5 (best 0.82) |
| Q5JWF2 | AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit alpha… | predicted | A | — | — |
Ligands
- GDP · Guanosine-5'-diphosphate · in 1 record
Experiment against prediction
- 5G53 chain D against the predicted model Q5JWF2: TM-score 0.93, RMSD 1.54 Å
- 5G53 chain D against the predicted model Q5JWF2: TM-score 0.93, RMSD 1.54 Å
- 5G53 chain D against the predicted model P63092: TM-score 0.92, RMSD 1.68 Å
- 5G53 chain D against the predicted model P63092: TM-score 0.92, RMSD 1.68 Å
- 5G53 chain C against the predicted model Q5JWF2: TM-score 0.91, RMSD 1.75 Å
- 5G53 chain C against the predicted model Q5JWF2: TM-score 0.91, RMSD 1.75 Å
- 5G53 chain C against the predicted model P63092: TM-score 0.90, RMSD 1.89 Å
- 5G53 chain C against the predicted model P63092: TM-score 0.90, RMSD 1.89 Å
- 8GY7 chain A against the predicted model Q5JWF2: TM-score 0.90, RMSD 2.12 Å
- 9BKK chain A against the predicted model Q5JWF2: TM-score 0.88, RMSD 1.95 Å
Elsewhere
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