UniProt Q54A96
Dihydroorotate dehydrogenase (Q54A96)
Dihydroorotate dehydrogenase (UniProt Q54A96), EC 1.3.3.1, 1.3.5.2: 11 experimental structures on GenesisL1, 8 ligands bound, 68 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q54A96
- Protein
- Dihydroorotate dehydrogenase
- EC
- 1.3.3.1, 1.3.5.2
- Experimental structures
- 11
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 68 · 11 records with a druggable one
Structures
11 records of Q54A96 in the MolNFT archive: 11 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4CQ8 | Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with Genz-669178 | x-ray diffraction | A, B | FMN, ORO, JBW | 6 (best 0.82) |
| 4CQ8 | Plasmodium falciparum dihydroorotate dehydrogenase (dhodh) in complex with genz-669178 | x-ray diffraction | A, B | FMN, ORO, JBW | 6 (best 0.82) |
| 4CQ9 | Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with IDI-6253 | x-ray diffraction | A, B | FMN, ORO, XBL | 7 (best 0.86) |
| 4CQ9 | Plasmodium falciparum dihydroorotate dehydrogenase (dhodh) in complex with idi-6253 | x-ray diffraction | A, B | FMN, ORO, XBL | 7 (best 0.86) |
| 4CQA | Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with IDI-6273 | x-ray diffraction | A, B | FMN, ORO, ID6 | 7 (best 0.86) |
| 4CQA | Plasmodium falciparum dihydroorotate dehydrogenase (dhodh) in complex with idi-6273 | x-ray diffraction | A, B | FMN, ORO, ID6 | 7 (best 0.86) |
| 6I4B | Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) co-crystallized with… | x-ray diffraction | A, B | FMN, ORO, E2N | 7 (best 0.84) |
| 6I4B | Plasmodium falciparum dihydroorotate dehydrogenase (dhodh) co- crystallized with… | x-ray diffraction | A, B | FMN, ORO, E2N | 7 (best 0.84) |
| 6I55 | Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) co-crystallized with… | x-ray diffraction | A, B | FMN, ORO, DZB | 5 (best 0.83) |
| 6I55 | Plasmodium falciparum dihydroorotate dehydrogenase (dhodh) co- crystallized with… | x-ray diffraction | A, B | FMN, ORO, DZB | 5 (best 0.83) |
| 7WYF | Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with its inhibitor 50 | x-ray diffraction | A | FMN, ORO, 7NE | 4 (best 0.85) |
Ligands
- FMN · Flavin mononucleotide · in 11 records
- ORO · Orotic acid · in 11 records
- DZB · N-(2,2-Diphenylethyl)-4-hydroxy-1,2,5-thiadiazole-3-carboxamide · in 2 records
- E2N · 1-methyl-3-oxidanyl-5-[[3-(trifluoromethyl) phenoxy]methyl]pyrazole-4-carboxylic acid · in 2 records
- ID6 · 2-(4-chlorobenzyl)-8-ethoxy-1,3-dimethylcyclohepta[c]pyrrol-4(2H)-one · in 2 records
- JBW · 5-(4-cyano-2-methyl-1H-benzimidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide · in 2 records
- XBL · 6-(3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-[1,2,4]triazolo[3,4-a]phthalazine · in 2 records
- 7NE · ethyl 2-(naphthalen-2-ylamino)-4-oxidanylidene-furan-3-carboxylate · in 1 record
Elsewhere
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