UniProt Q53U08
Neamine transaminase NeoN (Q53U08)
Neamine transaminase NeoN (UniProt Q53U08), EC 2.6.1.93, 2.6.1.95: 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 57 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q53U08
- Protein
- Neamine transaminase NeoN
- EC
- 2.6.1.93, 2.6.1.95
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 57 · 5 records with a druggable one
Structures
9 records of Q53U08 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6CBK | X-ray structure of NeoB from Streptomyces fradiae in complex with PMP | x-ray diffraction | A, B, C, D | PMP, NA | 19 (best 0.82) |
| 6CBK | X-ray structure of neob from streptomyces fradiae in complex with pmp | x-ray diffraction | A, B, C, D | PMP, NA | — |
| 6CBL | x-ray structure of NeoB from Streptomyces fradiae in complex with neamine as an external aldimine | x-ray diffraction | A, B, C, D, E, F, G, H | DOW, CL | 20 (best 0.78) |
| 6CBL | X-ray structure of neob from streptomyces fradiae in complex with neamine as an external aldimine | x-ray diffraction | A, B, C, D, E, F, G, H | DOW, CL | — |
| 6CBM | x-ray structure of NeoB from streptomyces fradiae in complex with PLP and neomycin (as the external… | x-ray diffraction | A, B | OZY, CL | 7 (best 0.75) |
| 6CBM | X-ray structure of neob from streptomyces fradiae in complex with plp and neomycin (as the external… | x-ray diffraction | A, B | OZY, CL | — |
| 6CBN | x-ray structure of NeoB from streptomyces fradiae in complex with PLP and neomycin (as the external… | x-ray diffraction | A, B | OZY | 6 (best 0.77) |
| 6CBN | X-ray structure of neob from streptomyces fradiae in complex with plp and neomycin (as the external… | x-ray diffraction | A, B | OZY | — |
| Q53U08 | AlphaFold monomer V2.0 prediction for neamine transaminase neon (Q53U08) | predicted | A | — | 5 (best 0.62) |
Ligands
- CL · Chloride ion · in 4 records
- OZY · (1R,2R,3S,4R,6S)-4,6-diamino-2-[(3-O-{2-amino-2,6-dideoxy-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy) methyl]pyridin-4-yl}methyl)amino]-alpha-D-glucopyranosyl}-beta-D-ribofuranosyl)oxy]-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside · in 4 records
- DOW · (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-alpha-D-glucopyranoside · in 2 records
- NA · Sodium ion · in 2 records
- PMP · 4'-deoxy-4'-aminopyridoxal-5'-phosphate · in 2 records
Experiment against prediction
- 6CBK chain A against the predicted model Q53U08: TM-score 1.00, RMSD 0.34 Å
- 6CBK chain A against the predicted model Q53U08: TM-score 1.00, RMSD 0.34 Å
- 6CBM chain A against the predicted model Q53U08: TM-score 1.00, RMSD 0.34 Å
- 6CBM chain A against the predicted model Q53U08: TM-score 1.00, RMSD 0.34 Å
- 6CBM chain B against the predicted model Q53U08: TM-score 1.00, RMSD 0.35 Å
- 6CBL chain A against the predicted model Q53U08: TM-score 1.00, RMSD 0.35 Å
- 6CBL chain A against the predicted model Q53U08: TM-score 1.00, RMSD 0.35 Å
- 6CBN chain A against the predicted model Q53U08: TM-score 1.00, RMSD 0.35 Å
- 6CBN chain A against the predicted model Q53U08: TM-score 1.00, RMSD 0.35 Å
- 6CBN chain B against the predicted model Q53U08: TM-score 1.00, RMSD 0.36 Å
Elsewhere
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