UniProt Q4WQS0
Extracellular sialidase/neuraminidase, putative (Q4WQS0)
Extracellular sialidase/neuraminidase, putative (UniProt Q4WQS0), EC 3.2.1.18: 14 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 51 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q4WQS0
- Protein
- Extracellular sialidase/neuraminidase, putative
- EC
- 3.2.1.18
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 51 · 12 records with a druggable one
Structures
15 records of Q4WQS0 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2XCY | Crystal structure of Aspergillus fumigatus sialidase | x-ray diffraction | A, B | CL | 4 (best 0.78) |
| 2XCY | Crystal structure of aspergillus fumigatus sialidase | x-ray diffraction | A, B | CL | 4 (best 0.78) |
| 2XZI | The aspergillus fumigatus sialidase is a kdnase: structural and mechanistic insights | x-ray diffraction | A, B | KDM, NA, NO2 | 4 (best 0.79) |
| 2XZI | The aspergillus fumigatus sialidase is a kdnase: structural and mechanistic insights | x-ray diffraction | A, B | KDM, NA, NO2 | 4 (best 0.79) |
| 2XZJ | The aspergillus fumigatus sialidase is a kdnase: structural and mechanistic insights | x-ray diffraction | A, B | NA, KFN | 4 (best 0.78) |
| 2XZJ | The aspergillus fumigatus sialidase is a kdnase: structural and mechanistic insights | x-ray diffraction | A, B | NA, KFN | 4 (best 0.78) |
| 2XZK | The aspergillus fumigatus sialidase is a kdnase: structural and mechanistic insights | x-ray diffraction | A, B | FKD, K99, NO3, NA, CL | 6 (best 0.77) |
| 2XZK | The aspergillus fumigatus sialidase is a kdnase: structural and mechanistic insights | x-ray diffraction | A, B | FKD, K99, NO3, NA, CL | 6 (best 0.77) |
| 4M4N | Structural evaluation the Y358H mutant of the aspergillus fumigatus kdnase (sialidase) | x-ray diffraction | A, B | NA | 4 (best 0.78) |
| 4M4N | Structural evaluation the Y358H mutant of the aspergillus fumigatus kdnase (sialidase) | x-ray diffraction | A, B | — | — |
| 4M4U | Structural evaluation D84A mutant of the aspergillus fumigatus kdnase (sialidase) | x-ray diffraction | A, B | NA, PO4, CL, NO3, NO2 | 4 (best 0.78) |
| 4M4U | Structural evaluation D84A mutant of the aspergillus fumigatus kdnase (sialidase) | x-ray diffraction | A, B | — | — |
| 4M4V | Structural evaluation R171L mutant of the aspergillus fumigatus kdnase (sialidase) | x-ray diffraction | A, B | DAN, NO3, NA | 5 (best 0.79) |
| 4M4V | Structural evaluation R171L mutant of the aspergillus fumigatus kdnase (sialidase) | x-ray diffraction | A, B | — | — |
| Q4WQS0 | AlphaFold monomer V2.0 prediction for exo-alpha-sialidase (Q4WQS0) | predicted | A | — | 2 (best 0.64) |
Ligands
- NA · Sodium ion · in 9 records
- CL · Chloride ion · in 5 records
- NO3 · Nitrate ion · in 4 records
- NO2 · Nitrite ion · in 3 records
- FKD · 3-deoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid · in 2 records
- K99 · (2R,3R,4R,5R,6S)-2,3-bis(fluoranyl)-4,5-bis(oxidanyl)-6-[(1R,2R)-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid · in 2 records
- KDM · deamino-alpha-neuraminic acid · in 2 records
- KFN · 2,6-anhydro-3-deoxy-D-glycero-D-galacto-non-2-enonic acid · in 2 records
- DAN · 2-deoxy-2,3-dehydro-N-acetyl-neuraminic acid · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 2XZI chain A against the predicted model Q4WQS0: TM-score 1.00, RMSD 0.16 Å
- 2XZI chain A against the predicted model Q4WQS0: TM-score 1.00, RMSD 0.16 Å
- 4M4U chain A against the predicted model Q4WQS0: TM-score 1.00, RMSD 0.17 Å
- 4M4U chain A against the predicted model Q4WQS0: TM-score 1.00, RMSD 0.17 Å
- 2XCY chain A against the predicted model Q4WQS0: TM-score 1.00, RMSD 0.19 Å
- 2XCY chain A against the predicted model Q4WQS0: TM-score 1.00, RMSD 0.19 Å
- 4M4N chain A against the predicted model Q4WQS0: TM-score 1.00, RMSD 0.20 Å
- 4M4N chain A against the predicted model Q4WQS0: TM-score 1.00, RMSD 0.20 Å
- 2XZJ chain A against the predicted model Q4WQS0: TM-score 1.00, RMSD 0.22 Å
- 2XZJ chain A against the predicted model Q4WQS0: TM-score 1.00, RMSD 0.22 Å
Elsewhere
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