UniProt Q4WLM9

Alpha,alpha-trehalose-phosphate synthase (UDP-forming) (Q4WLM9)

Alpha,alpha-trehalose-phosphate synthase (UDP-forming) (UniProt Q4WLM9), EC 2.4.1.15: 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 21 pockets. Binding sites, druggability and experiment against…

UniProt: Q4WLM9
Protein: Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
EC: 2.4.1.15
Experimental structures: 2
Predicted models: 1
Ligands: 2
Pockets: 21 · 3 records with a druggable one

Structures

3 records of Q4WLM9 in the MolNFT archive: 2 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5HVM	Structure of Aspergillus fumigatus trehalose-6-phosphate synthase A in complex with UDP and…	x-ray diffraction	A, B	UDP, VDM	8 (best 0.75)
5HVM	Structure of aspergillus fumigatus trehalose-6-phosphate synthase a in complex with udp and…	x-ray diffraction	A, B	UDP, VDM	8 (best 0.75)
Q4WLM9	AlphaFold monomer V2.0 prediction for ALPHA,ALPHA-trehalose-phosphate synthase [udp-forming] 1…	predicted	A	—	5 (best 0.75)

Ligands

UDP · Uridine-5'-diphosphate · in 2 records
VDM · (1S,2S,3R,6S)-4-(hydroxymethyl)-6-{[(1S,2S,3S,4R,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl]amino}cyclohex-4-ene-1,2,3-triol · in 2 records

Experiment against prediction

5HVM chain A against the predicted model Q4WLM9: TM-score 0.99, RMSD 0.92 Å
5HVM chain A against the predicted model Q4WLM9: TM-score 0.99, RMSD 0.92 Å
5HVM chain B against the predicted model Q4WLM9: TM-score 0.98, RMSD 1.12 Å
5HVM chain B against the predicted model Q4WLM9: TM-score 0.98, RMSD 1.12 Å

Elsewhere

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