UniProt Q4WHW0

ALPHA,ALPHA-trehalose-phosphate synthase [udp-forming] 2 (Q4WHW0)

ALPHA,ALPHA-trehalose-phosphate synthase [udp-forming] 2 (UniProt Q4WHW0): 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction…

UniProt: Q4WHW0
Protein: ALPHA,ALPHA-trehalose-phosphate synthase [udp-forming] 2
Experimental structures: 2
Predicted models: 1
Ligands: 2
Pockets: 1 · 1 record with a druggable one

Structures

3 records of Q4WHW0 in the MolNFT archive: 2 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5HVO	Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and…	x-ray diffraction	A, B, C, D	UDP, VDM	—
5HVO	Structure of aspergillus fumigatus trehalose-6-phosphate synthase B in complex with udp and…	x-ray diffraction	A, B, C, D	—	—
Q4WHW0	AlphaFold monomer V2.0 prediction for ALPHA,ALPHA-trehalose-phosphate synthase [udp-forming] 2…	predicted	A	—	1 (best 0.77)

Ligands

UDP · Uridine-5'-diphosphate · in 1 record
VDM · (1S,2S,3R,6S)-4-(hydroxymethyl)-6-{[(1S,2S,3S,4R,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl]amino}cyclohex-4-ene-1,2,3-triol · in 1 record

Experiment against prediction

5HVO chain D against the predicted model Q4WHW0: TM-score 0.99, RMSD 1.01 Å
5HVO chain D against the predicted model Q4WHW0: TM-score 0.99, RMSD 1.01 Å
5HVO chain C against the predicted model Q4WHW0: TM-score 0.98, RMSD 1.06 Å
5HVO chain C against the predicted model Q4WHW0: TM-score 0.98, RMSD 1.06 Å
5HVO chain B against the predicted model Q4WHW0: TM-score 0.98, RMSD 1.05 Å
5HVO chain B against the predicted model Q4WHW0: TM-score 0.98, RMSD 1.05 Å
5HVO chain A against the predicted model Q4WHW0: TM-score 0.98, RMSD 1.09 Å
5HVO chain A against the predicted model Q4WHW0: TM-score 0.98, RMSD 1.09 Å

Elsewhere

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