UniProt Q4VGL6
Roquin-1 (Q4VGL6)
Roquin-1 (UniProt Q4VGL6), EC 2.3.2.27: 14 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 82 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q4VGL6
- Protein
- Roquin-1
- EC
- 2.3.2.27
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 82 · 11 records with a druggable one
Structures
15 records of Q4VGL6 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4QI0 | X-ray structure of the ROQ domain from murine Roquin-1 | x-ray diffraction | A, B | — | 2 (best 0.42) |
| 4QI0 | X-ray structure of the roq domain from murine roquin-1 | x-ray diffraction | A, B | — | 2 (best 0.42) |
| 4QI2 | X-ray structure of the ROQ domain from murine Roquin-1 in complex with a 23-mer Tnf-CDE RNA | x-ray diffraction | A, B, C, D | — | 9 (best 0.63) |
| 4QI2 | X-ray structure of the roq domain from murine roquin-1 in complex with a 23-mer TNF-cde RNA | x-ray diffraction | A, B, C, D | — | 9 (best 0.63) |
| 4TXA | Crystal structure of N-terminus of Roquin | x-ray diffraction | A | ZN | 5 (best 0.66) |
| 4TXA | Crystal structure of N-terminus of roquin | x-ray diffraction | A | ZN | 5 (best 0.66) |
| 5F5F | X-ray structure of Roquin ROQ domain in complex with a Selex-derived hexa-loop RNA motif | x-ray diffraction | A, C, E, G | — | 10 (best 0.80) |
| 5F5F | X-ray structure of roquin roq domain in complex with a selex-derived hexa-loop RNA motif | x-ray diffraction | A, C, E, G | — | 10 (best 0.80) |
| 5F5H | X-ray structure of Roquin ROQ domain in complex with Ox40 hexa-loop RNA motif | x-ray diffraction | A, B | — | 5 (best 0.75) |
| 5F5H | X-ray structure of roquin roq domain in complex with OX40 hexa-loop RNA motif | x-ray diffraction | A, B | — | 5 (best 0.75) |
| 6TQA | X-ray structure of Roquin ROQ domain in complex with a UCP3 CDE2 SL RNA motif | x-ray diffraction | A, B, C, D | CL, MG | 12 (best 0.67) |
| 6TQA | X-ray structure of roquin roq domain in complex with a UCP3 CDE2 sl RNA motif | x-ray diffraction | A, B, C, D | CL | — |
| 6TQB | X-ray structure of Roquin ROQ domain in complex with a UCP3 CDE1 SL RNA motif | x-ray diffraction | A | NA, CL | 2 (best 0.63) |
| 6TQB | X-ray structure of roquin roq domain in complex with a UCP3 CDE1 sl RNA motif | x-ray diffraction | A | NA | — |
| Q4VGL6 | AlphaFold monomer V2.0 prediction for roquin-1 (Q4VGL6) | predicted | A | — | 6 (best 0.70) |
Ligands
Experiment against prediction
- 5F5F chain G against the predicted model Q4VGL6: TM-score 0.99, RMSD 0.45 Å
- 5F5F chain G against the predicted model Q4VGL6: TM-score 0.99, RMSD 0.45 Å
- 5F5H chain A against the predicted model Q4VGL6: TM-score 0.99, RMSD 0.51 Å
- 5F5H chain A against the predicted model Q4VGL6: TM-score 0.99, RMSD 0.51 Å
- 6TQA chain B against the predicted model Q4VGL6: TM-score 0.99, RMSD 0.53 Å
- 6TQA chain B against the predicted model Q4VGL6: TM-score 0.99, RMSD 0.53 Å
- 6TQA chain C against the predicted model Q4VGL6: TM-score 0.99, RMSD 0.67 Å
- 6TQA chain C against the predicted model Q4VGL6: TM-score 0.99, RMSD 0.67 Å
- 4QI0 chain A against the predicted model Q4VGL6: TM-score 0.98, RMSD 0.66 Å
- 4QI0 chain A against the predicted model Q4VGL6: TM-score 0.98, RMSD 0.66 Å
Elsewhere
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