UniProt Q3UHJ0
AP2-associated protein kinase 1 (Q3UHJ0)
AP2-associated protein kinase 1 (UniProt Q3UHJ0), EC 2.7.11.1: 10 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q3UHJ0
- Protein
- AP2-associated protein kinase 1
- EC
- 2.7.11.1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 26 · 4 records with a druggable one
Structures
11 records of Q3UHJ0 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7LVH | Crystal structure of AP2 associated kinase 1 isoform 1 complexed with ligand… | x-ray diffraction | A, B | YFS, SO4, YFV | — |
| 7LVH | Crystal structure of AP2 associated kinase 1 isoform 1 complexed with ligand… | x-ray diffraction | A, B | YFS, SO4, YFV | — |
| 7LVI | Crystal structure of AP2 associated kinase 1 isoform 1 complexed with ligand… | x-ray diffraction | A, B | YFY, SO4, YFV | 6 (best 0.75) |
| 7LVI | Crystal structure of AP2 associated kinase 1 isoform 1 complexed with ligand… | x-ray diffraction | A, B | YFY, SO4, YFV | — |
| 7RJ6 | Crystal structure of AP2 associated kinase 1 isoform 1 complexed with ligand… | x-ray diffraction | A, B | YFV, SO4, 5OI | 7 (best 0.76) |
| 7RJ6 | Crystal structure of AP2 associated kinase 1 isoform 1 complexed with ligand… | x-ray diffraction | A, B | YFV, SO4, 5OI | — |
| 7RJ7 | Crystal structure of AP2 associated kinase 1 isoform 1 complexed with ligand… | x-ray diffraction | A, B | 5P6, SO4 | 8 (best 0.72) |
| 7RJ7 | Crystal structure of AP2 associated kinase 1 isoform 1 complexed with ligand… | x-ray diffraction | A, B | 5P6, SO4 | — |
| 7RJ8 | Crystal structure of AP2 associated kinase 1 isoform 1 complexed with ligand… | x-ray diffraction | A, B | 5QI, SO4, YFV | 5 (best 0.79) |
| 7RJ8 | Crystal structure of AP2 associated kinase 1 isoform 1 complexed with ligand… | x-ray diffraction | A, B | 5QI, SO4, YFV | — |
| Q3UHJ0 | AlphaFold monomer V2.0 prediction for AP2-associated protein kinase 1 (Q3UHJ0) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 10 records
- YFV · 5-[(4-aminopiperidin-1-yl)methyl]-N-{3-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]phenyl}pyrrolo[2,1-F][1,2, 4]triazin-4-amine · in 8 records
- 5OI · (1S)-1-[4-ethyl-6-(1,3-oxazol-5-yl)quinazolin-2-yl]-3-methylbutan-1-amine · in 2 records
- 5P6 · 2-[(1S)-1-amino-3-methylbutyl]-6-(pyridin-4-yl) quinoline-4-carbonitrile · in 2 records
- 5QI · N-[3-(difluoromethoxy)-4-(1,3-oxazol-5-yl)phenyl]-D-leucinamide · in 2 records
- YFS · N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-D-leucinamide · in 2 records
- YFY · (2R,3R)-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-3-(propan-2-yl)piperidine-2-carboxamide · in 2 records
Experiment against prediction
- 7RJ7 chain A against the predicted model Q3UHJ0: TM-score 0.99, RMSD 0.72 Å
- 7RJ7 chain A against the predicted model Q3UHJ0: TM-score 0.99, RMSD 0.72 Å
- 7LVH chain B against the predicted model Q3UHJ0: TM-score 0.99, RMSD 0.71 Å
- 7LVH chain B against the predicted model Q3UHJ0: TM-score 0.99, RMSD 0.71 Å
- 7LVI chain B against the predicted model Q3UHJ0: TM-score 0.98, RMSD 0.87 Å
- 7LVI chain B against the predicted model Q3UHJ0: TM-score 0.98, RMSD 0.87 Å
- 7LVI chain A against the predicted model Q3UHJ0: TM-score 0.98, RMSD 0.86 Å
- 7LVI chain A against the predicted model Q3UHJ0: TM-score 0.98, RMSD 0.86 Å
- 7RJ6 chain A against the predicted model Q3UHJ0: TM-score 0.98, RMSD 0.98 Å
- 7RJ6 chain A against the predicted model Q3UHJ0: TM-score 0.98, RMSD 0.98 Å
Elsewhere
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