UniProt Q3E792
40S ribosomal protein S25-A (Q3E792)
40S ribosomal protein S25-A (UniProt Q3E792): 108 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q3E792
- Protein
- 40S ribosomal protein S25-A
- Experimental structures
- 108
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 52 · 48 records with a druggable one
Structures
109 records of Q3E792 in the MolNFT archive: 108 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J6X | S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 5 degree rotation (Class II) | electron microscopy | 25 | — | — |
| 3J6Y | S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I) | electron microscopy | 25 | — | — |
| 3J77 | Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class… | electron microscopy | 25 | — | — |
| 3J78 | Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class… | electron microscopy | 25 | — | — |
| 4U3M | Crystal structure of Anisomycin bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U3N | Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U3U | Crystal structure of Cycloheximide bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U4N | Crystal structure of Edeine bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U4O | Crystal structure of Geneticin bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U4Q | Crystal structure of Homoharringtonine bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U4R | Crystal structure of Lactimidomycin bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U4U | Crystal structure of Lycorine bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U4Y | Crystal structure of Pactamycin bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U4Z | Crystal structure of Phyllanthoside bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U50 | Crystal structure of Verrucarin bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U51 | Crystal structure of Narciclasine bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U52 | Crystal structure of Nagilactone C bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U53 | Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U55 | Crystal structure of Cryptopleurine bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U56 | Crystal structure of Blasticidin S bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4U6F | Crystal structure of T-2 toxin bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 4V6I | Localization of the small subunit ribosomal proteins into a 6.1 A cryo-EM map of Saccharomyces… | electron microscopy | AV | — | — |
| 4V7R | Yeast 80S ribosome. | x-ray diffraction | AQ, CQ | — | — |
| 4V88 | The structure of the eukaryotic ribosome at 3.0 A resolution. | x-ray diffraction | AZ, CZ | — | — |
| 4V8Y | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | electron microscopy | AZ | — | — |
| 4V8Z | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | electron microscopy | AZ | — | — |
| 5DGF | Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA… | x-ray diffraction | D5, d5 | — | 1 (best 0.88) |
| 5DGV | Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA… | x-ray diffraction | D5, d5 | — | — |
| 5FCI | Structure of the vacant uL3 W255C mutant 80S yeast ribosome | x-ray diffraction | D5, d5 | — | 1 (best 0.88) |
| 5I4L | Crystal structure of Amicoumacin A bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | — |
| 5JUO | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | WB | — | 1 (best 0.87) |
| 5JUP | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | WB | — | — |
| 5JUS | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | WB | — | — |
| 5JUT | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | WB | — | — |
| 5JUU | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | WB | — | 1 (best 0.89) |
| 5LYB | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA… | x-ray diffraction | D5, d5 | MG | 1 (best 0.87) |
| 5M1J | Nonstop ribosomal complex bound with Dom34 and Hbs1 | electron microscopy | Z2 | — | 1 (best 0.87) |
| 5MC6 | Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae | electron microscopy | K | — | — |
| 5MEI | Crystal structure of Agelastatin A bound to the 80S ribosome | x-ray diffraction | a, d5 | — | — |
| 5NDG | Crystal structure of geneticin (G418) bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | 1 (best 0.89) |
| 5NDV | Crystal structure of Paromomycin bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | — | 2 (best 0.90) |
| 5NDW | Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome | x-ray diffraction | d5, D5 | — | 1 (best 0.89) |
| 5OBM | Crystal structure of Gentamicin bound to the yeast 80S ribosome | x-ray diffraction | D5, d5 | MG | 1 (best 0.89) |
| 5TGA | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA… | x-ray diffraction | D5, d5 | MG | 1 (best 0.88) |
| 5TGM | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA… | x-ray diffraction | D5, d5 | — | — |
| 6EML | Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae | electron microscopy | K | — | 1 (best 0.86) |
| 6EML | Cryo-EM structure of a late pre-40S ribosomal subunit from saccharomyces cerevisiae | electron microscopy | K | — | — |
| 6FAI | Structure of a eukaryotic cytoplasmic pre-40S ribosomal subunit | electron microscopy | Z | — | 1 (best 0.88) |
| 6FAI | Structure of a eukaryotic cytoplasmic pre-40S ribosomal subunit | electron microscopy | Z | — | — |
| 6GQ1 | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin) | electron microscopy | AP | — | — |
| 6GQB | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin) | electron microscopy | AP | — | — |
| 6GQV | Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP) | electron microscopy | AP | — | — |
| 6HHQ | Crystal structure of compound C45 bound to the yeast 80S ribosome | x-ray diffraction | a, d5 | — | — |
| 6I7O | The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways… | electron microscopy | K, Kb | — | — |
| 6Q8Y | Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex | electron microscopy | K | — | 1 (best 0.88) |
| 6RBD | State 1 of yeast Tsr1-TAP Rps20-Deltaloop pre-40S particles | electron microscopy | Z | — | 1 (best 0.87) |
| 6RBD | State 1 of yeast TSR1-tap RPS20-deltaloop pre-40S particles | electron microscopy | Z | — | — |
| 6RBE | State 2 of yeast TSR1-tap RPS20-deltaloop pre-40S particles | electron microscopy | Z | — | — |
| 6SNT | Yeast 80S ribosome stalled on SDD1 mRNA. | electron microscopy | Z | — | 1 (best 0.87) |
| 6SV4 | The cryo-EM structure of SDD1-stalled collided trisome. | electron microscopy | K, Kb, Kc | — | 1 (best 0.88) |
49 records more on the page itself.
Ligands
Experiment against prediction
- 5M1J chain Z2 against the predicted model Q3E792: TM-score 0.95, RMSD 0.71 Å
- 6SV4 chain K against the predicted model Q3E792: TM-score 0.95, RMSD 0.71 Å
- 5NDW chain d5 against the predicted model Q3E792: TM-score 0.94, RMSD 0.73 Å
- 4U55 chain d5 against the predicted model Q3E792: TM-score 0.94, RMSD 0.75 Å
- 5LYB chain d5 against the predicted model Q3E792: TM-score 0.94, RMSD 0.77 Å
- 4V88 chain CZ against the predicted model Q3E792: TM-score 0.94, RMSD 0.79 Å
- 5I4L chain d5 against the predicted model Q3E792: TM-score 0.94, RMSD 0.78 Å
- 5NDG chain d5 against the predicted model Q3E792: TM-score 0.94, RMSD 0.79 Å
- 4U4U chain d5 against the predicted model Q3E792: TM-score 0.94, RMSD 0.80 Å
- 4U4N chain d5 against the predicted model Q3E792: TM-score 0.94, RMSD 0.79 Å
Elsewhere
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