UniProt Q38SD2
Leucine-rich repeat serine/threonine-protein kinase 1 (Q38SD2)
Leucine-rich repeat serine/threonine-protein kinase 1 (UniProt Q38SD2), EC 2.7.11.1: 4 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 89 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q38SD2
- Protein
- Leucine-rich repeat serine/threonine-protein kinase 1
- EC
- 2.7.11.1
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 89 · 5 records with a druggable one
Structures
5 records of Q38SD2 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8E04 | Structure of monomeric LRRK1 | electron microscopy | A | GDP | 13 (best 0.73) |
| 8E05 | Structure of dimeric LRRK1 | electron microscopy | A, B | GDP | 20 (best 0.77) |
| 8E06 | Symmetry expansion of dimeric LRRK1 | electron microscopy | A | GDP | 16 (best 0.79) |
| 8FAC | Structure of the leucine-rich repeat kinase 1 monomer | electron microscopy | A | GDP | 20 (best 0.82) |
| Q38SD2 | AlphaFold monomer V2.0 prediction for leucine-rich repeat SERINE/THREONINE-protein kinase 1 (Q38SD2) | predicted | A | — | 20 (best 0.84) |
Ligands
- GDP · Guanosine-5'-diphosphate · in 4 records
Experiment against prediction
- 8E05 chain A against the predicted model Q38SD2: TM-score 0.81, RMSD 6.15 Å
- 8E06 chain A against the predicted model Q38SD2: TM-score 0.81, RMSD 6.19 Å
- 8E04 chain A against the predicted model Q38SD2: TM-score 0.79, RMSD 6.18 Å
- 8FAC chain A against the predicted model Q38SD2: TM-score 0.77, RMSD 6.54 Å
Elsewhere
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