UniProt Q2VEQ7
D-2-hydroxyacid dehydrogenase (Q2VEQ7)
D-2-hydroxyacid dehydrogenase (UniProt Q2VEQ7), EC 1.1.1.-: 6 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q2VEQ7
- Protein
- D-2-hydroxyacid dehydrogenase
- EC
- 1.1.1.-
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 21 · 3 records with a druggable one
Structures
7 records of Q2VEQ7 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5MH5 | D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with 2-keto-hexanoic… | x-ray diffraction | A, B | MG, 7N5, NAP, SO4 | 5 (best 0.76) |
| 5MH5 | D-2-hydroxyacid dehydrogenases (D2-hdh) from haloferax mediterranei in complex with 2-keto-hexanoic… | x-ray diffraction | A, B | MG, 7N5, NAP, SO4 | — |
| 5MH6 | D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with 2-ketohexanoic… | x-ray diffraction | A, B, C, D | SO4, MG, NAD, 7N5, NA | 11 (best 0.78) |
| 5MH6 | D-2-hydroxyacid dehydrogenases (D2-hdh) from haloferax mediterranei in complex with 2-ketohexanoic… | x-ray diffraction | A, B, C, D | SO4, MG, NAD, 7N5, NA | — |
| 5MHA | D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with a mixture of… | x-ray diffraction | A, B | MG, 7N5, NDP, SO4, 7N6 | 5 (best 0.75) |
| 5MHA | D-2-hydroxyacid dehydrogenases (D2-hdh) from haloferax mediterranei in complex with a mixture of… | x-ray diffraction | A, B | MG, 7N5, NDP, SO4, 7N6 | — |
| Q2VEQ7 | AlphaFold monomer V2.0 prediction for D-2-hydroxyacid dehydrogenase (Q2VEQ7) | predicted | A | — | — |
Ligands
- 7N5 · 2-Ketohexanoic acid · in 6 records
- MG · Magnesium ion · in 6 records
- SO4 · Sulfate ion · in 6 records
- 7N6 · (2R)-2-hydroxyhexanoic acid · in 2 records
- NA · Sodium ion · in 2 records
- NAD · Nicotinamide-adenine-dinucleotide · in 2 records
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 2 records
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 2 records
Experiment against prediction
- 5MH6 chain B against the predicted model Q2VEQ7: TM-score 0.97, RMSD 1.10 Å
- 5MH6 chain B against the predicted model Q2VEQ7: TM-score 0.97, RMSD 1.10 Å
- 5MH6 chain C against the predicted model Q2VEQ7: TM-score 0.97, RMSD 1.19 Å
- 5MH6 chain C against the predicted model Q2VEQ7: TM-score 0.97, RMSD 1.19 Å
- 5MH5 chain B against the predicted model Q2VEQ7: TM-score 0.96, RMSD 1.28 Å
- 5MH5 chain B against the predicted model Q2VEQ7: TM-score 0.96, RMSD 1.28 Å
- 5MH6 chain A against the predicted model Q2VEQ7: TM-score 0.96, RMSD 1.31 Å
- 5MH6 chain A against the predicted model Q2VEQ7: TM-score 0.96, RMSD 1.31 Å
- 5MHA chain B against the predicted model Q2VEQ7: TM-score 0.96, RMSD 1.37 Å
- 5MHA chain B against the predicted model Q2VEQ7: TM-score 0.96, RMSD 1.37 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.