UniProt Q2TW47
Imine reductase (Q2TW47)
Imine reductase (UniProt Q2TW47), EC 1.5.1.48: 4 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q2TW47
- Protein
- Imine reductase
- EC
- 1.5.1.48
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 22 · 3 records with a druggable one
Structures
5 records of Q2TW47 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5G6R | Imine reductase from Aspergillus oryzae | x-ray diffraction | A, B | NDP | 3 (best 0.73) |
| 5G6R | Imine reductase from aspergillus oryzae | x-ray diffraction | A, B | — | — |
| 5G6S | Imine reductase from Aspergillus oryzae in complex with NADP(H) and (R)-rasagiline | x-ray diffraction | A, B, C, D, E, F, G, H | NDP, RAU | 17 (best 0.78) |
| 5G6S | Imine reductase from aspergillus oryzae in complex with NADP(H) and (R)-rasagiline | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| Q2TW47 | AlphaFold monomer V2.0 prediction for NADPH-dependent reductive aminase (Q2TW47) | predicted | A | — | 2 (best 0.54) |
Ligands
Experiment against prediction
- 5G6R chain B against the predicted model Q2TW47: TM-score 0.99, RMSD 0.73 Å
- 5G6R chain B against the predicted model Q2TW47: TM-score 0.99, RMSD 0.73 Å
- 5G6R chain A against the predicted model Q2TW47: TM-score 0.98, RMSD 0.91 Å
- 5G6R chain A against the predicted model Q2TW47: TM-score 0.98, RMSD 0.91 Å
- 5G6S chain C against the predicted model Q2TW47: TM-score 0.98, RMSD 0.91 Å
- 5G6S chain C against the predicted model Q2TW47: TM-score 0.98, RMSD 0.91 Å
- 5G6S chain A against the predicted model Q2TW47: TM-score 0.98, RMSD 0.94 Å
- 5G6S chain A against the predicted model Q2TW47: TM-score 0.98, RMSD 0.94 Å
Elsewhere
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