UniProt Q17RV3
non-specific serine/threonine protein kinase (Q17RV3)
non-specific serine/threonine protein kinase (UniProt Q17RV3), EC 2.7.11.1: 4 experimental structures on GenesisL1, 4 ligands bound, 21 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q17RV3
- Protein
- non-specific serine/threonine protein kinase
- EC
- 2.7.11.1
- Experimental structures
- 4
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 21 · 2 records with a druggable one
Structures
4 records of Q17RV3 in the MolNFT archive: 4 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2ZEJ | Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2… | x-ray diffraction | A, B | — | — |
| 2ZEJ | Structure of the roc domain from the PARKINSON'S disease-associated leucine-rich repeat kinase 2… | x-ray diffraction | A, B | — | — |
| 8SMC | Cryo-EM structure of LRRK2 bound with type-I inhibitor DNL201 | electron microscopy | C | GDP, TVT | 16 (best 0.77) |
| 9C61 | Crystal structure of the human LRRK2 WDR domain in complex with CACHE1193-26 | x-ray diffraction | A, B | A1AUU, UNX | 5 (best 0.74) |
Ligands
- A1AUU · (4R)-4-[4-(5-fluoro-1H-indol-3-yl)piperidine-1-carbonyl]piperidin-2-one · in 1 record
- GDP · Guanosine-5'-diphosphate · in 1 record
- TVT · 2-methyl-2-(3-methyl-4-{[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1H-pyrazol-1-yl)propanenitrile · in 1 record
- UNX · Unknown atom or ion · in 1 record
Elsewhere
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