UniProt Q16825
Tyrosine-protein phosphatase non-receptor type 21 (Q16825)
Tyrosine-protein phosphatase non-receptor type 21 (UniProt Q16825), EC 3.1.3.48: 5 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 36 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q16825
- Protein
- Tyrosine-protein phosphatase non-receptor type 21
- EC
- 3.1.3.48
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 36 · 5 records with a druggable one
Structures
6 records of Q16825 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8GVL | PTPN21 FERM | x-ray diffraction | A, B | — | 9 (best 0.75) |
| 8GVV | PTPN21 PTP domain C1108S mutant | x-ray diffraction | A | PO4, IOD | 1 (best 0.43) |
| 8GWH | PTPN21 PTP domain C1108S mutant in complex with SRC pTyr530 peptide | x-ray diffraction | A | — | 4 (best 0.52) |
| 8GXE | PTPN21 FERM PTP complex | x-ray diffraction | A, B | CL | 8 (best 0.59) |
| 8Y8Y | Crystal structure of the PTPN21 FERM domain | x-ray diffraction | A | CL | 4 (best 0.58) |
| Q16825 | AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 21 (Q16825) | predicted | A | — | 10 (best 0.72) |
Ligands
Experiment against prediction
- 8GXE chain A against the predicted model Q16825: TM-score 0.99, RMSD 0.79 Å
- 8GVV chain A against the predicted model Q16825: TM-score 0.98, RMSD 1.06 Å
- 8GWH chain A against the predicted model Q16825: TM-score 0.97, RMSD 1.55 Å
- 8GVL chain A against the predicted model Q16825: TM-score 0.97, RMSD 1.30 Å
- 8GXE chain B against the predicted model Q16825: TM-score 0.97, RMSD 1.21 Å
- 8Y8Y chain A against the predicted model Q16825: TM-score 0.96, RMSD 1.33 Å
- 8GVL chain B against the predicted model Q16825: TM-score 0.94, RMSD 1.64 Å
Elsewhere
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