UniProt Q15121
Astrocytic phosphoprotein PEA-15 (Q15121)
Astrocytic phosphoprotein PEA-15 (UniProt Q15121): 8 experimental structures and 1 predicted model on GenesisL1, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15121
- Protein
- Astrocytic phosphoprotein PEA-15
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 1 · 0 records with a druggable one
Structures
9 records of Q15121 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4IZ5 | Structure of the complex between ERK2 phosphomimetic mutant and PEA-15 | x-ray diffraction | E, F, G, H | — | — |
| 4IZ5 | Structure of the complex between ERK2 phosphomimetic mutant and pea-15 | x-ray diffraction | E, F, G, H | — | — |
| 4IZA | Structure of Dually Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain | x-ray diffraction | B | — | — |
| 4IZA | Structure of dually phosphorylated ERK2 bound to the pea-15 death effector domain | x-ray diffraction | B | — | — |
| 6P6B | CS-Rosetta Model of PEA-15 Death Effector Domain | solution nmr | A | — | — |
| 6P6B | Cs-rosetta model of pea-15 death effector domain | solution nmr | A | — | — |
| 6P6C | CS-Rosetta Model of PEA-15 Death Effector Domain in the Complex with ERK2 | solution nmr | A | — | — |
| 6P6C | Cs-rosetta model of pea-15 death effector domain in the complex with ERK2 | solution nmr | A | — | — |
| Q15121 | AlphaFold monomer V2.0 prediction for astrocytic phosphoprotein pea-15 (Q15121) | predicted | A | — | 1 (best 0.49) |
Experiment against prediction
- 4IZ5 chain H against the predicted model Q15121: TM-score 0.95, RMSD 0.78 Å
- 4IZ5 chain H against the predicted model Q15121: TM-score 0.95, RMSD 0.78 Å
- 4IZ5 chain E against the predicted model Q15121: TM-score 0.89, RMSD 0.77 Å
- 4IZ5 chain E against the predicted model Q15121: TM-score 0.89, RMSD 0.77 Å
- 6P6B chain A against the predicted model Q15121: TM-score 0.87, RMSD 1.31 Å
- 6P6B chain A against the predicted model Q15121: TM-score 0.87, RMSD 1.31 Å
- 4IZA chain B against the predicted model Q15121: TM-score 0.86, RMSD 0.94 Å
- 4IZA chain B against the predicted model Q15121: TM-score 0.86, RMSD 0.94 Å
- 6P6C chain A against the predicted model Q15121: TM-score 0.61, RMSD 2.93 Å
- 6P6C chain A against the predicted model Q15121: TM-score 0.61, RMSD 2.93 Å
Elsewhere
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