UniProt Q15109
Advanced glycosylation end product-specific receptor (Q15109)
Advanced glycosylation end product-specific receptor (UniProt Q15109): 49 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction…
- UniProt
- Q15109
- Protein
- Advanced glycosylation end product-specific receptor
- Experimental structures
- 49
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 1 · 0 records with a druggable one
Structures
50 records of Q15109 in the MolNFT archive: 49 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2E5E | Solution Structure of Variable-type Domain of Human Receptor for Advanced Glycation Endproducts | solution nmr | A | — | — |
| 2E5E | Solution structure of variable-type domain of human receptor for advanced glycation endproducts | solution nmr | A | — | — |
| 2ENS | Solution structure of the third ig-like domain from human Advanced glycosylation end… | solution nmr | A | — | — |
| 2ENS | Solution structure of the third ig-like domain from human advanced glycosylation end… | solution nmr | A | — | — |
| 2L7U | Structure of CEL-PEP-RAGE V domain complex | solution nmr | A | — | — |
| 2L7U | Structure of cel-pep-rage V domain complex | solution nmr | A | — | — |
| 2LE9 | RAGEC2-S100A13 tetrameric complex | solution nmr | A, D | — | — |
| 2LE9 | RAGEC2-S100A13 tetrameric complex | solution nmr | A, D | — | — |
| 2LMB | Solution Structure of C-terminal RAGE (ctRAGE) | solution nmr | A | — | — |
| 2LMB | Solution structure of C-terminal rage (ctrage) | solution nmr | A | — | — |
| 2M1K | Interaction of Human S100A6 (C3S) with V domain of Receptor for Advanced Glycation End products… | solution nmr | A, C | — | — |
| 2M1K | Interaction of human S100A6 (C3S) with V domain of receptor for advanced glycation end products… | solution nmr | A, C | — | — |
| 2MJW | Structural Insights into Calcium Bound S100P - V Domain of the receptor for advanced glycation end… | solution nmr | A, C | — | — |
| 2MJW | Structural insights into calcium bound S100P - V domain of the receptor for advanced glycation end… | solution nmr | A, C | — | — |
| 2MOV | Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal Derived… | solution nmr | A | — | — |
| 2MOV | Receptor for advanced glycation end products (rage) specifically recognizes methylglyoxal derived… | solution nmr | A | — | — |
| 3CJJ | Crystal structure of human rage ligand-binding domain | x-ray diffraction | A | — | — |
| 3CJJ | Crystal structure of human rage ligand-binding domain | x-ray diffraction | A | — | — |
| 3O3U | Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE) | x-ray diffraction | N | — | — |
| 3O3U | Crystal structure of human receptor for advanced glycation endproducts (rage) | x-ray diffraction | N | — | — |
| 4LP4 | Crystal structure of the human RAGE VC1 fragment in space group P62 | x-ray diffraction | A, B | — | — |
| 4LP4 | Crystal structure of the human rage VC1 fragment in space group P62 | x-ray diffraction | A, B | — | — |
| 4LP5 | Crystal structure of the full-length human RAGE extracellular domain (VC1C2 fragment) | x-ray diffraction | B, A | — | — |
| 4LP5 | Crystal structure of the full-length human rage extracellular domain (VC1C2 fragment) | x-ray diffraction | B, A | — | — |
| 4OF5 | Refinement of RAGE-DNA complex in 3S59 without DNA | x-ray diffraction | A, B | — | — |
| 4OF5 | Refinement of rage-DNA complex in 3S59 without DNA | x-ray diffraction | A, B | — | — |
| 4OFV | Refinement of RAGE-DNA complex in 3S58 without DNA | x-ray diffraction | A, B | — | — |
| 4OFV | Refinement of rage-DNA complex in 3S58 without DNA | x-ray diffraction | A, B | — | — |
| 4OI7 | RAGE recognizes nucleic acids and promotes inflammatory responses to DNA | x-ray diffraction | A, B | — | — |
| 4OI7 | Rage recognizes nucleic acids and promotes inflammatory responses to DNA | x-ray diffraction | A, B | — | — |
| 4OI8 | RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. | x-ray diffraction | A, B | — | — |
| 4OI8 | Rage is a nucleic acid receptor that promotes inflammatory responses to DNA. | x-ray diffraction | A, B | — | — |
| 4P2Y | Crystal structure of the human RAGE ectodomain (fragment VC1C2) in complex with mouse S100A6 | x-ray diffraction | A | — | — |
| 4P2Y | Crystal structure of the human rage ectodomain (fragment VC1C2) in complex with mouse S100A6 | x-ray diffraction | A | — | — |
| 4YBH | Crystal structure of the human RAGE ectodomain (VC1C2 fragment) in complex with human S100A6 | x-ray diffraction | A | — | — |
| 4YBH | Crystal structure of the human rage ectodomain (VC1C2 fragment) in complex with human S100A6 | x-ray diffraction | A | — | — |
| 5D7F | X-ray structure of CA(2+)-S100B with human rage-derived W72 peptide | x-ray diffraction | P | — | — |
| 6VXG | Structure of the C-terminal Domain of RAGE and Its Inhibitor | solution nmr | A | RQV | — |
| 6VXG | Structure of the C-terminal domain of rage and its inhibitor | solution nmr | A | RQV | — |
| 6XQ1 | Receptor for advanced glycation end products VC1 domain in complex with… | x-ray diffraction | A, B | CL, V74 | — |
| 6XQ3 | Receptor for Advanced Glycation End Products VC1 domain in complex with… | x-ray diffraction | A, B | CL, V6Y | — |
| 6XQ3 | Receptor for advanced glycation end products VC1 domain in complex with… | x-ray diffraction | A, B | CL, V6Y | — |
| 6XQ5 | Receptor for advanced glycation end products VC1 domain in complex with fragment 1 | x-ray diffraction | A, B | CL, V6M | — |
| 6XQ6 | Receptor for advanced glycation end products VC1 domain in complex with fragment 11 | x-ray diffraction | A, B | CL, V6P | — |
| 6XQ7 | Receptor for advanced glycation end products VC1 domain in complex with fragment 5 | x-ray diffraction | A, B | V6V, CL | — |
| 6XQ8 | Receptor for advanced glycation end products VC1 domain in complex with fragments 1 & 11 | x-ray diffraction | A, B | V6M, V6P, CL | — |
| 6XQ9 | Receptor for advanced glycation end products VC1 domain in complex with fragments 1 & 13 | x-ray diffraction | A, B | V6S, V6M | — |
| 7LML | Receptor for advanced glycation end products VC1 domain in complex with… | x-ray diffraction | A, B | CL, Y6S | — |
| 7LMW | Receptor for advanced glycation end products VC1 domain in complex with… | x-ray diffraction | A, B | Y6P, CL | — |
| Q15109 | AlphaFold monomer V2.0 prediction for advanced glycosylation end product-specific receptor (Q15109) | predicted | A | — | 1 (best 0.38) |
Ligands
- CL · Chloride ion · in 9 records
- V6M · 7-methyl-3-phenyl-1H-indole-2-carboxylic acid · in 3 records
- RQV · N-(4-{7-cyano-4-[(morpholin-4-yl)methyl]quinolin-2-yl}phenyl)acetamide · in 2 records
- V6P · 3-phenoxyphenol · in 2 records
- V6Y · 3-(3-{[3-(4-carboxyphenoxy)phenyl]methoxy}phenyl)-1H-indole-2-carboxylic acid · in 2 records
- V6S · 4-(3-hydroxyphenoxy)benzoic acid · in 1 record
- V6V · 5-bromo-3-methyl-1H-indole-2-carboxylic acid · in 1 record
- V74 · 3-[3-({[3-(4-carboxyphenoxy)phenyl]methoxy}methyl) phenyl]-1H-indole-2-carboxylic acid · in 1 record
- Y6P · 7-methyl-3-(1~{H}-pyrazol-4-yl)-1~{H}-indole-2-carboxylic acid · in 1 record
- Y6S · 6-iodanyl-1~{H}-indole-2-carboxylic acid · in 1 record
Experiment against prediction
- 4LP5 chain B against the predicted model Q15109: TM-score 0.97, RMSD 1.00 Å
- 4LP5 chain B against the predicted model Q15109: TM-score 0.97, RMSD 1.00 Å
- 4OFV chain A against the predicted model Q15109: TM-score 0.97, RMSD 1.02 Å
- 4OFV chain A against the predicted model Q15109: TM-score 0.97, RMSD 1.02 Å
- 4OF5 chain B against the predicted model Q15109: TM-score 0.97, RMSD 1.05 Å
- 4OF5 chain B against the predicted model Q15109: TM-score 0.97, RMSD 1.05 Å
- 4OF5 chain A against the predicted model Q15109: TM-score 0.97, RMSD 1.04 Å
- 4OF5 chain A against the predicted model Q15109: TM-score 0.97, RMSD 1.04 Å
- 4OFV chain B against the predicted model Q15109: TM-score 0.97, RMSD 1.12 Å
- 4OFV chain B against the predicted model Q15109: TM-score 0.97, RMSD 1.12 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.