UniProt Q15046
Lysine--tRNA ligase (Q15046)
Lysine--tRNA ligase (UniProt Q15046), EC 2.7.7.-, 6.1.1.6: 14 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q15046
- Protein
- Lysine--tRNA ligase
- EC
- 2.7.7.-, 6.1.1.6
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 31 · 3 records with a druggable one
Structures
15 records of Q15046 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3BJU | Crystal Structure of tetrameric form of human lysyl-tRNA synthetase | x-ray diffraction | A, B, C, D | — | — |
| 3BJU | Crystal structure of tetrameric form of human lysyl-tRNA synthetase | x-ray diffraction | A, B, C, D | — | — |
| 4DPG | Crystal Structure of Human LysRS: P38/AIMP2 Complex I | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4DPG | Crystal structure of human lysrs: P38/AIMP2 complex I | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4YCU | Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase | x-ray diffraction | A, B | — | — |
| 4YCU | Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase | x-ray diffraction | A, B | — | — |
| 4YCW | Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant | x-ray diffraction | A, B, E, F | — | — |
| 4YCW | Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant | x-ray diffraction | A, B, E, F | — | — |
| 6CHD | Crystal Structure of Human Lysyl-tRNA Synthetase complexed with L-Lysylsulfamoyl Adenosine | x-ray diffraction | A, B | KAA, SO4 | 10 (best 0.84) |
| 6CHD | Crystal structure of human lysyl-tRNA synthetase complexed with L- lysylsulfamoyl adenosine | x-ray diffraction | A, B | SO4 | — |
| 6ILD | Crystal structure of human lysrs: P38/AIMP2 complex II | x-ray diffraction | A, B | MG, 45A | — |
| 6ILH | Crystal structure of human lysyl-tRNA synthetase L350H mutant | x-ray diffraction | A, B | — | — |
| 7EA9 | Crystal structure of human lysyl-tRNA synthetase Y145H mutant | x-ray diffraction | A, B, C, D | — | — |
| 8HYR | Crystal structure of human KARS apo | x-ray diffraction | A, B | — | 13 (best 0.81) |
| Q15046 | AlphaFold monomer V2.0 prediction for lysine--tRNA ligase (Q15046) | predicted | A | — | 8 (best 0.79) |
Ligands
Experiment against prediction
- 4DPG chain B against the predicted model Q15046: TM-score 1.00, RMSD 0.43 Å
- 4DPG chain B against the predicted model Q15046: TM-score 1.00, RMSD 0.43 Å
- 4DPG chain H against the predicted model Q15046: TM-score 0.99, RMSD 0.45 Å
- 4DPG chain H against the predicted model Q15046: TM-score 0.99, RMSD 0.45 Å
- 4DPG chain D against the predicted model Q15046: TM-score 0.99, RMSD 0.45 Å
- 4DPG chain D against the predicted model Q15046: TM-score 0.99, RMSD 0.45 Å
- 3BJU chain B against the predicted model Q15046: TM-score 0.99, RMSD 0.54 Å
- 3BJU chain B against the predicted model Q15046: TM-score 0.99, RMSD 0.54 Å
- 3BJU chain D against the predicted model Q15046: TM-score 0.99, RMSD 0.57 Å
- 3BJU chain D against the predicted model Q15046: TM-score 0.99, RMSD 0.57 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.