UniProt Q14573
Inositol 1,4,5-trisphosphate receptor type 3 (Q14573)
Inositol 1,4,5-trisphosphate receptor type 3 (UniProt Q14573): 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 120 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q14573
- Protein
- Inositol 1,4,5-trisphosphate receptor type 3
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 120 · 6 records with a druggable one
Structures
9 records of Q14573 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6DR2 | Ca2+-bound human type 3 1,4,5-inositol trisphosphate receptor | electron microscopy | A, B, C, D | ZN, CA | 20 (best 0.86) |
| 6DRA | Low IP3 Ca2+ human type 3 1,4,5-inositol trisphosphate receptor | electron microscopy | A, B, C, D | ZN, CA | 20 (best 0.85) |
| 6DRC | High IP3 Ca2+ human type 3 1,4,5-inositol trisphosphate receptor | electron microscopy | A, B, C, D | ZN, I3P, CA | 20 (best 0.84) |
| 7T3P | IP3 and ATP bound type 3 IP3 receptor in the pre-active A state | electron microscopy | A, B, C, D | ZN, I3P, ATP | 20 (best 0.84) |
| 7T3T | IP3, ATP, and Ca2+ bound type 3 IP3 receptor in the active state | electron microscopy | A, B, C, D | ZN, I3P, ATP, CA | — |
| 7T3U | IP3, ATP, and CA2+ bound type 3 IP3 receptor in the inactive state | electron microscopy | A, B, C, D | ZN, I3P, ATP, CA | — |
| 8TK8 | Human Type 3 IP3 Receptor - Resting State (+IP3/ATP) | electron microscopy | A, B, C, D | ZN, I3P, ATP, PCW | 20 (best 0.83) |
| 8TKE | Human Type 3 IP3 Receptor - Preactivated+Ca2+ State (+IP3/ATP/JD Ca2+) | electron microscopy | A, B, C, D | ZN, I3P, CA, ATP | 20 (best 0.83) |
| Q14573 | AlphaFold monomer V2.0 prediction for inositol 1,4,5-trisphosphate receptor type 3 (Q14573) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8TK8 chain C against the predicted model Q14573: TM-score 0.95, RMSD 3.30 Å
- 8TK8 chain A against the predicted model Q14573: TM-score 0.95, RMSD 3.30 Å
- 8TK8 chain D against the predicted model Q14573: TM-score 0.95, RMSD 3.30 Å
- 8TK8 chain B against the predicted model Q14573: TM-score 0.95, RMSD 3.28 Å
- 7T3P chain D against the predicted model Q14573: TM-score 0.85, RMSD 5.89 Å
- 7T3P chain B against the predicted model Q14573: TM-score 0.85, RMSD 5.89 Å
- 7T3P chain C against the predicted model Q14573: TM-score 0.85, RMSD 5.89 Å
- 7T3P chain A against the predicted model Q14573: TM-score 0.85, RMSD 5.89 Å
- 8TKE chain A against the predicted model Q14573: TM-score 0.83, RMSD 6.22 Å
- 8TKE chain D against the predicted model Q14573: TM-score 0.83, RMSD 6.23 Å
Elsewhere
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