UniProt Q14565
Meiotic recombination protein DMC1/LIM15 homolog (Q14565)
Meiotic recombination protein DMC1/LIM15 homolog (UniProt Q14565): 18 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 77 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q14565
- Protein
- Meiotic recombination protein DMC1/LIM15 homolog
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 77 · 6 records with a druggable one
Structures
19 records of Q14565 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1V5W | Crystal structure of the human Dmc1 protein | x-ray diffraction | A, B | — | 6 (best 0.67) |
| 1V5W | Crystal structure of the human DMC1 protein | x-ray diffraction | A, B | — | — |
| 2ZJB | Crystal structure of the human Dmc1-M200V polymorphic variant | x-ray diffraction | A, B | — | — |
| 2ZJB | Crystal structure of the human DMC1-M200V polymorphic variant | x-ray diffraction | A, B | — | — |
| 4HYY | Filament of octameric rings of DMC1 recombinase from Homo sapiens | x-ray diffraction | A, B, C, D | — | — |
| 4HYY | Filament of octameric rings of DMC1 recombinase from homo sapiens | x-ray diffraction | A, B, C, D | — | — |
| 6R3P | Crystal structure of human DMC1 ATPase domain | x-ray diffraction | A, B, C, D | — | 11 (best 0.73) |
| 6R3P | Crystal structure of human DMC1 ATPase domain | x-ray diffraction | A, B, C, D | — | — |
| 7C98 | Human DMC1 post-synaptic complexes | electron microscopy | A, B, C | CA, ANP | 20 (best 0.78) |
| 7C98 | Human DMC1 post-synaptic complexes | electron microscopy | A, B, C | CA, ANP | — |
| 7C99 | Human DMC1 post-synaptic complexes with mismatched dsDNA | electron microscopy | A, B, C | CA, ANP | — |
| 7C99 | Human DMC1 post-synaptic complexes with mismatched dsdna | electron microscopy | A, B, C | CA, ANP | — |
| 7C9C | Human DMC1 pre-synaptic complexes | electron microscopy | A, B, C | CA, ANP | — |
| 7C9C | Human DMC1 pre-synaptic complexes | electron microscopy | A, B, C | CA, ANP | — |
| 7CGY | Human DMC1 Q244M mutant of the post-synaptic complexes | electron microscopy | A, B, C | CA, ANP | 15 (best 0.82) |
| 7CGY | Human DMC1 Q244M mutant of the post-synaptic complexes | electron microscopy | A, B, C | CA, ANP | — |
| 8QQE | Crystal structure of the complex between DMC1 and the PhePP domain of BRCA2 | x-ray diffraction | A, B | MG, CL | 5 (best 0.67) |
| 8R2G | Crystal structure of a BRCA2-DMC1 complex | x-ray diffraction | A, B, C, D, E, F, G, H | — | 20 (best 0.71) |
| Q14565 | AlphaFold monomer V2.0 prediction for meiotic recombination protein DMC1/LIM15 homolog (Q14565) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7CGY chain A against the predicted model Q14565: TM-score 0.98, RMSD 0.85 Å
- 7CGY chain A against the predicted model Q14565: TM-score 0.98, RMSD 0.85 Å
- 7CGY chain C against the predicted model Q14565: TM-score 0.98, RMSD 0.87 Å
- 7CGY chain C against the predicted model Q14565: TM-score 0.98, RMSD 0.87 Å
- 7CGY chain B against the predicted model Q14565: TM-score 0.98, RMSD 0.87 Å
- 7CGY chain B against the predicted model Q14565: TM-score 0.98, RMSD 0.87 Å
- 7C9C chain B against the predicted model Q14565: TM-score 0.98, RMSD 0.96 Å
- 7C9C chain B against the predicted model Q14565: TM-score 0.98, RMSD 0.96 Å
- 7C99 chain C against the predicted model Q14565: TM-score 0.98, RMSD 0.97 Å
- 7C99 chain C against the predicted model Q14565: TM-score 0.98, RMSD 0.97 Å
Elsewhere
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