UniProt Q14562
ATP-dependent RNA helicase DHX8 (Q14562)
ATP-dependent RNA helicase DHX8 (UniProt Q14562), EC 3.6.4.13: 21 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q14562
- Protein
- ATP-dependent RNA helicase DHX8
- EC
- 3.6.4.13
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 7 · 5 records with a druggable one
Structures
22 records of Q14562 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2EQS | Solution structure of the S1 RNA binding domain of human ATP-dependent RNA helicase DHX8 | solution nmr | A | — | — |
| 2EQS | Solution structure of the S1 RNA binding domain of human ATP-dependent RNA helicase DHX8 | solution nmr | A | — | — |
| 3I4U | Crystal Structure Analysis of a helicase associated domain | x-ray diffraction | A | — | — |
| 3I4U | Crystal structure analysis of a helicase associated domain | x-ray diffraction | A | — | — |
| 5MQF | Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex) | electron microscopy | q | — | — |
| 5MQF | Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex) | electron microscopy | q | — | — |
| 5XJC | Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | electron microscopy | Y | — | — |
| 6HYS | Crystal structure of DHX8 helicase domain bound to ADP at 2.6 ångström | x-ray diffraction | A, B, C, D | ADP, MG | — |
| 6HYT | Crystal structure of DHX8 helicase domain bound to ADP at 2.3 Angstrom | x-ray diffraction | A, B, C, D | ADP, MG, CL | — |
| 6HYT | Crystal structure of DHX8 helicase domain bound to ADP at 2.3 ångström | x-ray diffraction | A, B, C, D | ADP, MG, CL | — |
| 6HYU | Crystal structure of DHX8 helicase bound to single stranded poly-adenine RNA | x-ray diffraction | A, C | — | — |
| 6HYU | Crystal structure of DHX8 helicase bound to single stranded poly- adenine RNA | x-ray diffraction | A, C | — | — |
| 6ICZ | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom | electron microscopy | Y | — | 1 (best 0.82) |
| 6ICZ | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 ångström | electron microscopy | Y | — | — |
| 7W59 | The cryo-EM structure of human pre-C*-I complex | electron microscopy | Y | — | 2 (best 0.83) |
| 7W59 | The cryo-EM structure of human pre-C*-I complex | electron microscopy | Y | — | — |
| 7W5A | The cryo-EM structure of human pre-C*-II complex | electron microscopy | Y | — | — |
| 7W5A | The cryo-EM structure of human pre-C*-II complex | electron microscopy | Y | — | — |
| 7W5B | The cryo-EM structure of human C* complex | electron microscopy | Y | — | 2 (best 0.82) |
| 8C6J | Human spliceosomal PM5 C* complex | electron microscopy | V | — | 1 (best 0.85) |
| 9FMD | Integrative model of the human post-catalytic spliceosome (P-complex) | electron microscopy | V | — | 1 (best 0.84) |
| Q14562 | AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase DHX8 (Q14562) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3I4U chain A against the predicted model Q14562: TM-score 0.96, RMSD 1.63 Å
- 3I4U chain A against the predicted model Q14562: TM-score 0.96, RMSD 1.63 Å
- 6HYU chain A against the predicted model Q14562: TM-score 0.95, RMSD 2.04 Å
- 6HYU chain A against the predicted model Q14562: TM-score 0.95, RMSD 2.04 Å
- 6HYT chain B against the predicted model Q14562: TM-score 0.94, RMSD 2.28 Å
- 6HYT chain B against the predicted model Q14562: TM-score 0.94, RMSD 2.28 Å
- 6HYT chain A against the predicted model Q14562: TM-score 0.94, RMSD 2.31 Å
- 6HYT chain A against the predicted model Q14562: TM-score 0.94, RMSD 2.31 Å
- 6HYS chain B against the predicted model Q14562: TM-score 0.94, RMSD 2.24 Å
- 6HYS chain A against the predicted model Q14562: TM-score 0.94, RMSD 2.41 Å
Elsewhere
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