UniProt Q13464
Q13464
Q13464 (UniProt Q13464): 48 experimental structures on GenesisL1, 11 ligands bound. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q13464
- Experimental structures
- 48
- Predicted models
- 0
- Ligands
- 11
Structures
48 records of Q13464 in the MolNFT archive: 48 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1S1C | Crystal structure of the complex between the human RhoA and Rho-binding domain of human ROCKI | x-ray diffraction | X, Y | — | — |
| 1S1C | Crystal structure of the complex between the human rhoa and rho-binding domain of human rocki | x-ray diffraction | X, Y | — | — |
| 2ESM | Crystal Structure of ROCK 1 bound to fasudil | x-ray diffraction | A, B | — | — |
| 2ESM | Crystal structure of rock 1 bound to fasudil | x-ray diffraction | A, B | — | — |
| 2ETK | Crystal Structure of ROCK 1 bound to hydroxyfasudil | x-ray diffraction | A, B | — | — |
| 2ETK | Crystal structure of rock 1 bound to hydroxyfasudil | x-ray diffraction | A, B | — | — |
| 2ETR | Crystal Structure of ROCK I bound to Y-27632 | x-ray diffraction | A, B | — | — |
| 2ETR | Crystal structure of rock I bound to Y-27632 | x-ray diffraction | A, B | — | — |
| 2V55 | Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure | x-ray diffraction | A, C | — | — |
| 2V55 | Mechanism of multi-site phosphorylation from a rock-I:RHOE complex structure | x-ray diffraction | A, C | — | — |
| 3D9V | Crystal structure of rock I bound to H-1152P a di-methylated variant of fasudil | x-ray diffraction | A, B | — | — |
| 3D9V | Crystal structure of rock I bound to H-1152P a di- methylated variant of fasudil | x-ray diffraction | A, B | — | — |
| 3NCZ | X-Ray Co-structure of Rho-Associated Protein Kinase (ROCK1) with a potent 2H-isoquinolin-1-one… | x-ray diffraction | A, B, C, D | — | — |
| 3NCZ | X-ray co-structure of rho-associated protein kinase (ROCK1) with a potent 2H-isoquinolin-1-one… | x-ray diffraction | A, B, C, D | — | — |
| 3NDM | Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative | x-ray diffraction | A, B, C, D | — | — |
| 3NDM | Crystal structure of rho-associated protein kinase (ROCK1) with a potent isoquinolone derivative | x-ray diffraction | A, B, C, D | — | — |
| 3O0Z | Crystal structure of a coiled-coil domain from human ROCK I | x-ray diffraction | A, B, C, D | — | — |
| 3O0Z | Crystal structure of a coiled-coil domain from human rock I | x-ray diffraction | A, B, C, D | — | — |
| 3TV7 | Human Rho-associated protein kinase 1 (ROCK 1) in COMPLEX WITH RKI1342 | x-ray diffraction | A, B, C, D | — | — |
| 3TV7 | Human rho-associated protein kinase 1 (rock 1) in complex with RKI1342 | x-ray diffraction | A, B, C, D | — | — |
| 3TWJ | Rho-associated protein kinase 1 (ROCK 1) IN COMPLEX WITH RKI1447 | x-ray diffraction | A, B, C, D | — | — |
| 3TWJ | Rho-associated protein kinase 1 (rock 1) in complex with RKI1447 | x-ray diffraction | A, B, C, D | — | — |
| 3V8S | Human RHO-ASSOCIATED PROTEIN KINASE 1 (ROCK 1) IN COMPLEX WITH INDAZOLE DERIVATIVE (COMPOUND 18) | x-ray diffraction | A, B, C, D | — | — |
| 3V8S | Human rho-associated protein kinase 1 (rock 1) in complex with indazole derivative (compound 18) | x-ray diffraction | A, B, C, D | — | — |
| 4L2W | Crystal structure of the Shroom-Binding domain of human Rock1 | x-ray diffraction | C, D, A, B | — | — |
| 4L2W | Crystal structure of the shroom-binding domain of human ROCK1 | x-ray diffraction | C, D, A, B | — | — |
| 4W7P | Crystal Structure of ROCK 1 bound to YB-15-QD37 | x-ray diffraction | A, B, C, D | — | — |
| 4W7P | Crystal structure of rock 1 bound to yb-15-QD37 | x-ray diffraction | A, B, C, D | — | — |
| 4YVC | ROCK 1 bound to thiazole inhibitor | x-ray diffraction | A, B | — | — |
| 4YVC | Rock 1 bound to thiazole inhibitor | x-ray diffraction | A, B | — | — |
| 4YVE | ROCK 1 bound to methoxyphenyl thiazole inhibitor | x-ray diffraction | A, B | — | — |
| 4YVE | Rock 1 bound to methoxyphenyl thiazole inhibitor | x-ray diffraction | A, B | — | — |
| 5BML | ROCK 1 bound to a pyridine thiazole inhibitor | x-ray diffraction | A, B | — | — |
| 5BML | Rock 1 bound to a pyridine thiazole inhibitor | x-ray diffraction | A, B | — | — |
| 5F5P | Molecular Basis for Shroom2 Recognition by Rock1 | x-ray diffraction | C, D, E, F | CL | — |
| 5F5P | Molecular basis for SHROOM2 recognition by ROCK1 | x-ray diffraction | C, D, E, F | — | — |
| 5HVU | Rho-associated protein kinase 1 (rock 1) in complex with a pyridine thiazole piperidine inhibitor | x-ray diffraction | A, B | — | — |
| 5KKS | ROCK 1 bound to azaindole thiazole inhibitor | x-ray diffraction | A, B | 6U1 | — |
| 5KKS | Rock 1 bound to azaindole thiazole inhibitor | x-ray diffraction | A, B | 6U1 | — |
| 5KKT | Rock 1 bound to azaindole thiazole piperazine inhibitor | x-ray diffraction | A, B | 6U2 | — |
| 5UZJ | Crystal structure of ROCK1 bound to an aminopyridine inhibitor | x-ray diffraction | A, B | 8UV | — |
| 5WNE | X-ray co-structure of rho-associated protein kinase (ROCK1) with a highly selective inhibitor | x-ray diffraction | A, B, C, D | B4J | — |
| 5WNF | X-ray co-structure of rho-associated protein kinase (ROCK1) with a highly selective inhibitor | x-ray diffraction | A, B, C, D | B4V | — |
| 5WNG | X-ray co-structure of rho-associated protein kinase (ROCK1) with a highly selective inhibitor | x-ray diffraction | A, B, C, D | B4Y | — |
| 5WNH | X-ray co-structure of rho-associated protein kinase (ROCK1) with a highly selective inhibitor | x-ray diffraction | A, B, C, D | B5G | — |
| 6E9W | Crystal structure of ROCK1 with a pyridinylbenzamide based inhibitor | x-ray diffraction | A, B | J0P, SO4 | — |
| 7JOU | Crystal structure of rho-associated protein kinase 1 (ROCK1) in complex with a phenylpyrazole amide… | x-ray diffraction | A | VFS | — |
| Q13464 | AlphaFold monomer V2.0 prediction for rho-associated protein kinase 1 (Q13464) | — | — | — |
Ligands
- 6U1 · 2-[3-(methylsulfonylamino)phenyl]-~{N}-[4-(1~{H}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide · in 2 records
- 6U2 · 2-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-~{N}-[4-(1~{H}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide · in 1 record
- 8UV · N-[4-(2-aminopyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide · in 1 record
- B4J · 3,4-dimethoxy-N-({3-[(5-methyl-4,5,6,7-tetrahydro[1, 3]thiazolo[5,4-c]pyridin-2-yl) carbamoyl]phenyl}methyl)benzamide · in 1 record
- B4V · 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-N-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1H-1,2,3-triazole-4-carboxamide · in 1 record
- B4Y · (2R)-N-(3-cyanophenyl)-2-(3-{[(6S)-6-(dimethylamino)-4, 5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamide · in 1 record
- B5G · (2R)-N-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl) carbamoyl]phenyl}pyrrolidine-1-carboxamide · in 1 record
- CL · Chloride ion · in 1 record
- J0P · N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide · in 1 record
- SO4 · Sulfate ion · in 1 record
- VFS · N-[(1S)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1H-pyrazol-4-yl)benzamide · in 1 record
Elsewhere
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