UniProt Q13421
Isoform 4 of Mesothelin (Q13421)
Isoform 4 of Mesothelin (UniProt Q13421): 11 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 53 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13421
- Protein
- Isoform 4 of Mesothelin
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 53 · 5 records with a druggable one
Structures
12 records of Q13421 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4F3F | Crystal Structure of Msln7-64 MORAb-009 FAB complex | x-ray diffraction | C | — | — |
| 4F3F | Crystal structure of MSLN7-64 morab-009 Fab complex | x-ray diffraction | C | — | — |
| 7U8C | Crystal structure of Mesothelin C-terminal peptide-MORAb 15B6 FAB complex | x-ray diffraction | BA2 | — | — |
| 7U9J | Crystal structure of Mesothelin-207 fragment | x-ray diffraction | A, B | SO4 | 1 (best 0.74) |
| 7UED | Crystal structure of full length mesothelin bound with MORAb-009 Fab | x-ray diffraction | M | NAG | 3 (best 0.70) |
| 8CX3 | Crystal structure of full-length mesothelin | x-ray diffraction | A, B, C, D, E, F | NAG, PO4 | 20 (best 0.64) |
| 8CXC | Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and… | x-ray diffraction | M | — | — |
| 8CYH | Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and… | x-ray diffraction | M | NAG | 1 (best 0.36) |
| 8CZ8 | Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and… | x-ray diffraction | M, E | SO4 | 8 (best 0.75) |
| 8FSL | Human Mesothelin bound to a neutralizing VH domain antibody | x-ray diffraction | E, F | — | 12 (best 0.71) |
| 8VM1 | Structural Elucidation of the Mesothelin Mucin16 CA125 Interaction | x-ray diffraction | A | NAG | 1 (best 0.41) |
| Q13421 | AlphaFold monomer V2.0 prediction for mesothelin (Q13421) | predicted | A | — | 7 (best 0.45) |
Ligands
Experiment against prediction
- 4F3F chain C against the predicted model Q13421: TM-score 0.97, RMSD 0.48 Å
- 4F3F chain C against the predicted model Q13421: TM-score 0.97, RMSD 0.48 Å
- 8CZ8 chain E against the predicted model Q13421: TM-score 0.95, RMSD 1.10 Å
- 8CZ8 chain M against the predicted model Q13421: TM-score 0.95, RMSD 1.15 Å
- 7U9J chain A against the predicted model Q13421: TM-score 0.78, RMSD 2.70 Å
- 7U9J chain B against the predicted model Q13421: TM-score 0.77, RMSD 2.91 Å
- 8CX3 chain D against the predicted model Q13421: TM-score 0.70, RMSD 3.97 Å
- 8CX3 chain F against the predicted model Q13421: TM-score 0.69, RMSD 4.06 Å
- 8CX3 chain E against the predicted model Q13421: TM-score 0.69, RMSD 4.08 Å
- 8CYH chain M against the predicted model Q13421: TM-score 0.69, RMSD 4.31 Å
Elsewhere
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