UniProt Q13237
cGMP-dependent protein kinase 2 (Q13237)
cGMP-dependent protein kinase 2 (UniProt Q13237), EC 2.7.11.12: 11 experimental structures on GenesisL1, 6 ligands bound, 3 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q13237
- Protein
- cGMP-dependent protein kinase 2
- EC
- 2.7.11.12
- Experimental structures
- 11
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 3 · 3 records with a druggable one
Structures
11 records of Q13237 in the MolNFT archive: 11 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5BV6 | PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with cGMP | x-ray diffraction | A | 35G, CA, NA | 1 (best 0.72) |
| 5BV6 | Pkg II'S carboxyl terminal cyclic nucleotide binding domain (cnb-B) in a complex with cgmp | x-ray diffraction | A | — | — |
| 5C6C | Pkg II'S amino terminal cyclic nucleotide binding domain (cnb-a) in a complex with camp | x-ray diffraction | A, B | — | — |
| 5C8W | PKG II's Amino Terminal Cyclic Nucleotide Binding Domain (CNB-A) in a complex with cGMP | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5C8W | Pkg II'S amino terminal cyclic nucleotide binding domain (cnb-a) in a complex with cgmp | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5JIX | PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-Br-cGMP | x-ray diffraction | A | CA, 6J7, NA | 1 (best 0.73) |
| 5JIX | Pkg II'S carboxyl terminal cyclic nucleotide binding domain (cnb-B) in a complex with 8-br-cgmp | x-ray diffraction | A | — | — |
| 5JIZ | PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-pCPT-cGMP | x-ray diffraction | A | 6FW, CA | 1 (best 0.73) |
| 5JIZ | Pkg II'S carboxyl terminal cyclic nucleotide binding domain (cnb-B) in a complex with 8-pcpt-cgmp | x-ray diffraction | A | — | — |
| 6BQ8 | Joint X-RAY/NEUTRON structure of pkg II cnb-B domain in complex with 8-pcpt-cgmp | x-ray diffraction; neutron diffraction | A | 6FW, SR | — |
| Q13237 | AlphaFold monomer V2.0 prediction for cgmp-dependent protein kinase 2 (Q13237) | — | — | — |
Ligands
- CA · Calcium ion · in 3 records
- 6FW · 2-amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2s,4ar,6r,7r, 7AS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3,9-dihydro-6H-purin-6-one · in 2 records
- NA · Sodium ion · in 2 records
- 35G · Guanosine-3',5'-monophosphate · in 1 record
- 6J7 · 2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one · in 1 record
- SR · Strontium ion · in 1 record
Elsewhere
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