UniProt Q08722
Leukocyte surface antigen CD47 (Q08722)
Leukocyte surface antigen CD47 (UniProt Q08722): 22 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q08722
- Protein
- Leukocyte surface antigen CD47
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 26 · 4 records with a druggable one
Structures
23 records of Q08722 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JJS | Structure of human CD47 in complex with human signal regulatory protein (SIRP) alpha | x-ray diffraction | C, D | — | — |
| 2JJS | Structure of human CD47 in complex with human signal regulatory protein (sirp) alpha | x-ray diffraction | C, D | — | — |
| 2JJT | Structure of human CD47 in complex with human signal regulatory protein (SIRP) alpha | x-ray diffraction | C, D | — | — |
| 2JJT | Structure of human CD47 in complex with human signal regulatory protein (sirp) alpha | x-ray diffraction | C, D | — | — |
| 2VSC | Structure of the immunoglobulin-superfamily ectodomain of human CD47 | x-ray diffraction | A, B, C, D | — | — |
| 2VSC | Structure of the immunoglobulin-superfamily ectodomain of human CD47 | x-ray diffraction | A, B, C, D | — | — |
| 4CMM | Structure of human CD47 in complex with human Signal Regulatory Protein (SIRP) alpha v1 | x-ray diffraction | B | — | — |
| 4CMM | Structure of human CD47 in complex with human signal regulatory protein (sirp) alpha V1 | x-ray diffraction | B | — | — |
| 4KJY | Complex of high-affinity SIRP alpha variant FD6 with CD47 | x-ray diffraction | A, C | — | — |
| 4KJY | Complex of high-affinity sirp alpha variant FD6 with CD47 | x-ray diffraction | A, C | — | — |
| 5IWL | CD47-diabody complex | x-ray diffraction | C, D | NAG | 2 (best 0.43) |
| 5IWL | CD47-diabody complex | x-ray diffraction | C, D | — | — |
| 5TZ2 | Crystal structure of human CD47 ECD bound to Fab of C47B222 | x-ray diffraction | C | NAG | — |
| 5TZ2 | Crystal structure of human CD47 ecd bound to Fab of C47B222 | x-ray diffraction | C | NAG | — |
| 5TZT | Crystal structure of human CD47 ECD bound to Fab of C47B161 | x-ray diffraction | C, D | NAG | 9 (best 0.73) |
| 5TZT | Crystal structure of human CD47 ecd bound to Fab of C47B161 | x-ray diffraction | C, D | NAG | — |
| 5TZU | Crystal structure of human CD47 ecd bound to Fab of B6H12.2 | x-ray diffraction | C | NAG | — |
| 7MYZ | Structure of the full length 5-TM receptor CD47 bound to Fab B6H12 | x-ray diffraction | C, D | NAG | 4 (best 0.55) |
| 7MYZ | Structure of the full length 5-tm receptor CD47 bound to Fab B6H12 | x-ray diffraction | C, D | NAG | — |
| 7WN8 | Crystal structure of antibody (BC31M5) binds to CD47 | x-ray diffraction | A, C | ZN | 6 (best 0.48) |
| 7YGG | Crystal structure of human CD47 in complex with engineered SIRPa.D1(N80A) | x-ray diffraction | C, D | NAG | 2 (best 0.56) |
| 8RP8 | Structure of K2 Fab in complex with human CD47 ECD | x-ray diffraction | C, D | NAG | 3 (best 0.61) |
| Q08722 | AlphaFold monomer V2.0 prediction for leukocyte surface antigen CD47 (Q08722) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2JJS chain D against the predicted model Q08722: TM-score 0.99, RMSD 0.34 Å
- 2JJS chain D against the predicted model Q08722: TM-score 0.99, RMSD 0.34 Å
- 5IWL chain D against the predicted model Q08722: TM-score 0.99, RMSD 0.37 Å
- 5IWL chain D against the predicted model Q08722: TM-score 0.99, RMSD 0.37 Å
- 7YGG chain C against the predicted model Q08722: TM-score 0.99, RMSD 0.38 Å
- 5IWL chain C against the predicted model Q08722: TM-score 0.99, RMSD 0.37 Å
- 5IWL chain C against the predicted model Q08722: TM-score 0.99, RMSD 0.37 Å
- 2JJT chain D against the predicted model Q08722: TM-score 0.99, RMSD 0.38 Å
- 2JJT chain D against the predicted model Q08722: TM-score 0.99, RMSD 0.38 Å
- 2JJS chain C against the predicted model Q08722: TM-score 0.99, RMSD 0.39 Å
Elsewhere
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