UniProt Q08109
ERAD-associated E3 ubiquitin-protein ligase HRD1 (Q08109)
ERAD-associated E3 ubiquitin-protein ligase HRD1 (UniProt Q08109), EC 2.3.2.27: 10 experimental structures and 1 predicted model on GenesisL1, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q08109
- Protein
- ERAD-associated E3 ubiquitin-protein ligase HRD1
- EC
- 2.3.2.27
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 33 · 5 records with a druggable one
Structures
11 records of Q08109 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5V6P | CryoEM structure of the ERAD-associated E3 ubiquitin-protein ligase HRD1 | electron microscopy | A, B | — | 5 (best 0.86) |
| 5V6P | Cryoem structure of the erad-associated E3 ubiquitin-protein ligase HRD1 | electron microscopy | A, B | — | — |
| 6VJY | Cryo-EM structure of Hrd1/Hrd3 monomer | electron microscopy | B | — | 9 (best 0.70) |
| 6VJY | Cryo-EM structure of HRD1/HRD3 monomer | electron microscopy | B | — | — |
| 6VJZ | CryoEM structure of Hrd1-Usa1/Der1/Hrd3 complex of the expected topology | electron microscopy | B | — | 5 (best 0.73) |
| 6VJZ | Cryoem structure of HRD1-USA1/DER1/HRD3 complex of the expected topology | electron microscopy | B | — | — |
| 6VK0 | CryoEM structure of Hrd1-Usa1/Der1/Hrd3 of the flipped topology | electron microscopy | B | — | 8 (best 0.68) |
| 6VK0 | Cryoem structure of HRD1-USA1/DER1/HRD3 of the flipped topology | electron microscopy | B | — | — |
| 6VK1 | CryoEM structure of Hrd1/Hrd3 part from Hrd1-Usa1/Der1/Hrd3 complex | electron microscopy | B | — | 6 (best 0.68) |
| 6VK1 | Cryoem structure of HRD1/HRD3 part from HRD1-USA1/DER1/HRD3 complex | electron microscopy | B | — | — |
| Q08109 | AlphaFold monomer V2.0 prediction for erad-associated E3 ubiquitin- protein ligase HRD1 (Q08109) | predicted | A | — | — |
Experiment against prediction
- 6VJZ chain B against the predicted model Q08109: TM-score 0.95, RMSD 1.34 Å
- 6VJZ chain B against the predicted model Q08109: TM-score 0.95, RMSD 1.34 Å
- 6VK1 chain B against the predicted model Q08109: TM-score 0.95, RMSD 1.48 Å
- 6VK1 chain B against the predicted model Q08109: TM-score 0.95, RMSD 1.48 Å
- 6VK0 chain B against the predicted model Q08109: TM-score 0.95, RMSD 1.49 Å
- 6VK0 chain B against the predicted model Q08109: TM-score 0.95, RMSD 1.49 Å
- 5V6P chain B against the predicted model Q08109: TM-score 0.93, RMSD 1.74 Å
- 5V6P chain A against the predicted model Q08109: TM-score 0.93, RMSD 1.74 Å
- 5V6P chain A against the predicted model Q08109: TM-score 0.93, RMSD 1.74 Å
- 6VJY chain B against the predicted model Q08109: TM-score 0.93, RMSD 1.73 Å
Elsewhere
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