UniProt Q07864
DNA polymerase epsilon catalytic subunit A (Q07864)
DNA polymerase epsilon catalytic subunit A (UniProt Q07864), EC 2.7.7.7, 3.1.11.-: 6 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 71 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q07864
- Protein
- DNA polymerase epsilon catalytic subunit A
- EC
- 2.7.7.7, 3.1.11.-
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 71 · 5 records with a druggable one
Structures
7 records of Q07864 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5VBN | Crystal structure of human DNA polymerase epsilon B-subunit in complex with C-terminal domain of… | x-ray diffraction | B, F | ZN | — |
| 7PLO | H. sapiens replisome-CUL2/LRR1 complex | electron microscopy | B | — | 1 (best 0.77) |
| 9F6E | Human DNA polymerase epsilon bound to DNA and PCNA (ajar conformation) | electron microscopy | A | SF4, DDS | 14 (best 0.74) |
| 9F6I | Human DNA Polymerase epsilon bound to T-C mismatched DNA (Post-Insertion state) | electron microscopy | A | SF4, DDS, CA | 16 (best 0.77) |
| 9F6K | Human DNA Polymerase epsilon bound to T-C mismatched DNA (Frayed Substrate state) | electron microscopy | A | SF4 | 20 (best 0.77) |
| 9F6L | Human DNA Polymerase epsilon bound to T-C mismatched DNA (Mismatch Excision state) | electron microscopy | A | SF4, CA | 20 (best 0.82) |
| Q07864 | AlphaFold monomer V2.0 prediction for DNA polymerase epsilon catalytic subunit a (Q07864) | predicted | A | — | — |
Ligands
Experiment against prediction
- 9F6I chain A against the predicted model Q07864: TM-score 0.97, RMSD 1.94 Å
- 9F6E chain A against the predicted model Q07864: TM-score 0.97, RMSD 2.38 Å
- 9F6L chain A against the predicted model Q07864: TM-score 0.94, RMSD 2.88 Å
- 5VBN chain B against the predicted model Q07864: TM-score 0.94, RMSD 1.13 Å
- 5VBN chain F against the predicted model Q07864: TM-score 0.94, RMSD 1.13 Å
- 9F6K chain A against the predicted model Q07864: TM-score 0.94, RMSD 3.14 Å
- 7PLO chain B against the predicted model Q07864: TM-score 0.88, RMSD 3.51 Å
Elsewhere
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