UniProt Q06135
1,3-beta-glucanosyltransferase GAS2 (Q06135)
1,3-beta-glucanosyltransferase GAS2 (UniProt Q06135), EC 2.4.1.-: 19 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q06135
- Protein
- 1,3-beta-glucanosyltransferase GAS2
- EC
- 2.4.1.-
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 14 · 3 records with a druggable one
Structures
20 records of Q06135 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2W61 | Saccharomyces cerevisiae Gas2p apostructure (E176Q mutant) | x-ray diffraction | A | — | — |
| 2W61 | Saccharomyces cerevisiae GAS2P apostructure (E176Q mutant) | x-ray diffraction | A | — | — |
| 2W62 | Saccharomyces cerevisiae Gas2p in complex with laminaripentaose | x-ray diffraction | A | — | — |
| 2W62 | Saccharomyces cerevisiae GAS2P in complex with laminaripentaose | x-ray diffraction | A | — | — |
| 2W63 | Saccharomyces cerevisiae GAS2P in complex with laminaritriose and laminaritetraose | x-ray diffraction | A | — | — |
| 2W63 | Saccharomyces cerevisiae GAS2P in complex with laminaritriose and laminaritetraose | x-ray diffraction | A | — | — |
| 5O9O | Crystal structure of ScGas2 in complex with compound 7. | x-ray diffraction | A | 9PB | 3 (best 0.52) |
| 5O9O | Crystal structure of SCGAS2 in complex with compound 7. | x-ray diffraction | A | 9PB | — |
| 5O9P | Crystal structure of Gas2 in complex with compound 10 | x-ray diffraction | A | 9P8 | 4 (best 0.49) |
| 5O9P | Crystal structure of GAS2 in complex with compound 10 | x-ray diffraction | A | 9P8 | — |
| 5O9Q | Crystal structure of ScGas2 in complex with compound 6 | x-ray diffraction | A | BGC, 9PH | 4 (best 0.51) |
| 5O9Q | Crystal structure of SCGAS2 in complex with compound 6 | x-ray diffraction | A | BGC, 9PH | — |
| 5O9R | Crystal structure of ScGas2 in complex with compound 9 | x-ray diffraction | A | BGC, 9PK, SO4 | — |
| 5O9R | Crystal structure of SCGAS2 in complex with compound 9 | x-ray diffraction | A | BGC, 9PK, SO4 | — |
| 5O9Y | Crystal structure of ScGas2 in complex with compound 11 | x-ray diffraction | A | 9PN, SO4 | — |
| 5O9Y | Crystal structure of SCGAS2 in complex with compound 11 | x-ray diffraction | A | 9PN, SO4 | — |
| 5OA2 | Crystal structure of SCGAS2 in complex with compound 8 | x-ray diffraction | A, B, C | BGC, SO4, 9PW | — |
| 5OA6 | Crystal structure of ScGas2 in complex with compound 12 | x-ray diffraction | A | 9PT, SO4 | 3 (best 0.51) |
| 5OA6 | Crystal structure of SCGAS2 in complex with compound 12 | x-ray diffraction | A | 9PT, SO4 | — |
| Q06135 | AlphaFold monomer V2.0 prediction for 1,3-beta-glucanosyltransferase GAS2 (Q06135) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 7 records
- BGC · beta-D-glucopyranose · in 5 records
- 9P8 · (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-3, 5-bis(oxidanyl)-6-[4-(pyridin-2-ylmethoxymethyl)-1,2, 3-triazol-1-yl]oxan-4-yl]oxy-3,5-bis(oxidanyl)oxan-4-yl]oxy-oxane-3,4,5-triol · in 2 records
- 9PB · (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-[4-(naphthalen-2-ylmethoxymethyl)-1,2,3-triazol-1-yl]-3,5-bis(oxidanyl)oxan-4-yl]oxy-3,5-bis(oxidanyl)oxan-4-yl]oxy-oxane-3,4,5-triol · in 2 records
- 9PH · (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-3, 5-bis(oxidanyl)-6-[4-(phenylmethoxymethyl)-1,2,3-triazol-1-yl]oxan-4-yl]oxy-3,5-bis(oxidanyl)oxan-4-yl]oxy-oxane-3,4,5-triol · in 2 records
- 9PK · (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-3,5-bis(oxidanyl)-6-[4-(thiophen-2-ylmethoxymethyl)-1,2,3-triazol-1-yl]oxan-4-yl]oxy-3,5-bis(oxidanyl)oxan-4-yl]oxy-oxane-3,4,5-triol · in 2 records
- 9PN · (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-3,5-bis(oxidanyl)-6-[4-(3-pyridin-1-ium-1-ylpropyl)-1,2,3-triazol-1-yl]oxan-4-yl]oxy-3,5-bis(oxidanyl)oxan-4-yl]oxy-oxane-3,4,5-triol · in 2 records
- 9PT · (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-3, 5-bis(oxidanyl)-6-[4-(3-quinolin-1-ium-1-ylpropyl)-1, 2,3-triazol-1-yl]oxan-4-yl]oxy-3,5-bis(oxidanyl)oxan-4-yl]oxy-oxane-3,4,5-triol · in 2 records
- 9PW · [4-[[1-[(2~{R},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-4-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-4-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3,5-bis(oxidanyl)oxan-2-yl]oxy-3,5-bis(oxidanyl)oxan-2-yl]-1,2,3-triazol-4-yl]methoxymethyl]phenyl]-oxidanyl-oxidanylidene-azanium · in 1 record
Experiment against prediction
- 2W61 chain A against the predicted model Q06135: TM-score 0.99, RMSD 0.71 Å
- 2W61 chain A against the predicted model Q06135: TM-score 0.99, RMSD 0.71 Å
- 5OA2 chain B against the predicted model Q06135: TM-score 0.99, RMSD 0.86 Å
- 5OA2 chain A against the predicted model Q06135: TM-score 0.98, RMSD 0.97 Å
- 5OA2 chain C against the predicted model Q06135: TM-score 0.98, RMSD 1.25 Å
- 2W62 chain A against the predicted model Q06135: TM-score 0.97, RMSD 1.30 Å
- 2W62 chain A against the predicted model Q06135: TM-score 0.97, RMSD 1.30 Å
- 5O9O chain A against the predicted model Q06135: TM-score 0.97, RMSD 1.31 Å
- 5O9O chain A against the predicted model Q06135: TM-score 0.97, RMSD 1.31 Å
- 5O9R chain A against the predicted model Q06135: TM-score 0.97, RMSD 1.38 Å
Elsewhere
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