UniProt Q05787
ERAD-associated E3 ubiquitin-protein ligase component HRD3 (Q05787)
ERAD-associated E3 ubiquitin-protein ligase component HRD3 (UniProt Q05787): 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 49 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q05787
- Protein
- ERAD-associated E3 ubiquitin-protein ligase component HRD3
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 49 · 5 records with a druggable one
Structures
11 records of Q05787 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5V7V | Cryo-EM structure of ERAD-associated E3 ubiquitin-protein ligase component HRD3 | electron microscopy | A | NAG | 9 (best 0.73) |
| 5V7V | Cryo-EM structure of erad-associated E3 ubiquitin-protein ligase component HRD3 | electron microscopy | A | NAG | — |
| 6VJY | Cryo-EM structure of Hrd1/Hrd3 monomer | electron microscopy | A | — | 10 (best 0.70) |
| 6VJY | Cryo-EM structure of HRD1/HRD3 monomer | electron microscopy | A | — | — |
| 6VJZ | CryoEM structure of Hrd1-Usa1/Der1/Hrd3 complex of the expected topology | electron microscopy | A | — | 11 (best 0.73) |
| 6VJZ | Cryoem structure of HRD1-USA1/DER1/HRD3 complex of the expected topology | electron microscopy | A | — | — |
| 6VK0 | CryoEM structure of Hrd1-Usa1/Der1/Hrd3 of the flipped topology | electron microscopy | A | — | 10 (best 0.69) |
| 6VK0 | Cryoem structure of HRD1-USA1/DER1/HRD3 of the flipped topology | electron microscopy | A | — | — |
| 6VK1 | CryoEM structure of Hrd1/Hrd3 part from Hrd1-Usa1/Der1/Hrd3 complex | electron microscopy | A | — | 9 (best 0.71) |
| 6VK1 | Cryoem structure of HRD1/HRD3 part from HRD1-USA1/DER1/HRD3 complex | electron microscopy | A | — | — |
| Q05787 | AlphaFold monomer V2.0 prediction for erad-associated E3 ubiquitin- protein ligase component HRD3… | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
Experiment against prediction
- 6VK1 chain A against the predicted model Q05787: TM-score 0.99, RMSD 0.86 Å
- 6VK1 chain A against the predicted model Q05787: TM-score 0.99, RMSD 0.86 Å
- 6VJZ chain A against the predicted model Q05787: TM-score 0.99, RMSD 0.89 Å
- 6VJZ chain A against the predicted model Q05787: TM-score 0.99, RMSD 0.89 Å
- 6VK0 chain A against the predicted model Q05787: TM-score 0.99, RMSD 0.92 Å
- 6VK0 chain A against the predicted model Q05787: TM-score 0.99, RMSD 0.92 Å
- 6VJY chain A against the predicted model Q05787: TM-score 0.99, RMSD 0.94 Å
- 6VJY chain A against the predicted model Q05787: TM-score 0.99, RMSD 0.94 Å
- 5V7V chain A against the predicted model Q05787: TM-score 0.97, RMSD 1.48 Å
- 5V7V chain A against the predicted model Q05787: TM-score 0.97, RMSD 1.48 Å
Elsewhere
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