UniProt Q04002

Sister chromatid cohesion protein 2 (Q04002)

Sister chromatid cohesion protein 2 (UniProt Q04002): 6 experimental structures and 1 predicted model on GenesisL1, 77 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q04002
Protein: Sister chromatid cohesion protein 2
Experimental structures: 6
Predicted models: 1
Pockets: 77 · 7 records with a druggable one

Structures

7 records of Q04002 in the MolNFT archive: 6 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4XDN	Crystal structure of Scc4 in complex with Scc2n	x-ray diffraction	B	—	10 (best 0.76)
4XDN	Crystal structure of SCC4 in complex with SCC2N	x-ray diffraction	B	—	10 (best 0.76)
5W94	Crystal structure of Scc4 in complex with Scc2n and Ctf19n	x-ray diffraction	B, D	—	9 (best 0.78)
5W94	Crystal structure of SCC4 in complex with SCC2N and CTF19N	x-ray diffraction	B, D	—	9 (best 0.78)
6ZZ6	Cryo-EM structure of S.cerevisiae cohesin-Scc2-DNA complex	electron microscopy	D	—	12 (best 0.80)
6ZZ6	Cryo-EM structure of S.CEREVISIAE cohesin-SCC2-DNA complex	electron microscopy	D	—	12 (best 0.80)
Q04002	AlphaFold monomer V2.0 prediction for sister chromatid cohesion protein 2 (Q04002)	predicted	A	—	15 (best 0.73)

Experiment against prediction

6ZZ6 chain D against the predicted model Q04002: TM-score 0.93, RMSD 3.14 Å
6ZZ6 chain D against the predicted model Q04002: TM-score 0.93, RMSD 3.14 Å
5W94 chain D against the predicted model Q04002: TM-score 0.47, RMSD 4.68 Å
5W94 chain D against the predicted model Q04002: TM-score 0.47, RMSD 4.68 Å
4XDN chain B against the predicted model Q04002: TM-score 0.43, RMSD 4.84 Å
4XDN chain B against the predicted model Q04002: TM-score 0.43, RMSD 4.84 Å
5W94 chain B against the predicted model Q04002: TM-score 0.34, RMSD 5.38 Å
5W94 chain B against the predicted model Q04002: TM-score 0.34, RMSD 5.38 Å

Elsewhere

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