UniProt Q03579
Ceramide synthase subunit LIP1 (Q03579)
Ceramide synthase subunit LIP1 (UniProt Q03579): 3 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q03579
- Protein
- Ceramide synthase subunit LIP1
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 19 · 3 records with a druggable one
Structures
4 records of Q03579 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8IZD | Cryo-EM structure of the C26-CoA-bound Lac1-Lip1 complex | electron microscopy | B, D | 9NY, 6PL | 5 (best 0.81) |
| 8QTR | Cryo-EM structure of the FB-bound yeast Ceramide Synthase | electron microscopy | C, D | 7PO, 3PE, PIJ, NH4 | 7 (best 0.74) |
| 8Y2M | Cryo-EM structure of the FB1-bound Lac1-Lip1 complex | electron microscopy | B, D | 6PL | 7 (best 0.81) |
| Q03579 | AlphaFold monomer V2.0 prediction for ceramide synthase subunit LIP1 (Q03579) | predicted | A | — | — |
Ligands
- 6PL · (4S,7R)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide · in 2 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 1 record
- 7PO · hexacosanoic acid · in 1 record
- 9NY · Hexacosanoyl-CoA · in 1 record
- NH4 · Ammonium ion · in 1 record
- PIJ · [(2S)-1-hexadecanoyloxy-3-[hydroxy-[(2S,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] heptadecanoate · in 1 record
Experiment against prediction
- 8QTR chain D against the predicted model Q03579: TM-score 0.73, RMSD 1.85 Å
- 8IZD chain B against the predicted model Q03579: TM-score 0.73, RMSD 1.84 Å
- 8IZD chain D against the predicted model Q03579: TM-score 0.73, RMSD 1.84 Å
- 8QTR chain C against the predicted model Q03579: TM-score 0.73, RMSD 1.87 Å
- 8Y2M chain B against the predicted model Q03579: TM-score 0.72, RMSD 1.84 Å
Elsewhere
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