UniProt Q03532
ATP-dependent RNA helicase HAS1 (Q03532)
ATP-dependent RNA helicase HAS1 (UniProt Q03532), EC 3.6.4.13: 19 experimental structures and 1 predicted model on GenesisL1, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q03532
- Protein
- ATP-dependent RNA helicase HAS1
- EC
- 3.6.4.13
- Experimental structures
- 19
- Predicted models
- 1
- Pockets
- 20 · 10 records with a druggable one
Structures
20 records of Q03532 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5Z3G | Cryo-EM structure of a nucleolar pre-60S ribosome (Rpf1-TAP) | electron microscopy | Y | — | 1 (best 0.86) |
| 5Z3G | Cryo-EM structure of a nucleolar pre-60S ribosome (RPF1-tap) | electron microscopy | Y | — | — |
| 6C0F | Yeast nucleolar pre-60S ribosomal subunit (state 2) | electron microscopy | p | — | — |
| 6C0F | Yeast nucleolar pre-60S ribosomal subunit (state 2) | electron microscopy | p | — | — |
| 6ELZ | State E (TAP-Flag-Ytm1 E80A) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | electron microscopy | D | — | 2 (best 0.88) |
| 6EM3 | State A architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar… | electron microscopy | D | — | — |
| 6EM3 | State a architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of nucleolar… | electron microscopy | D | — | — |
| 6EM4 | State B architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of nucleolar… | electron microscopy | D | — | — |
| 6EM5 | State D architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar… | electron microscopy | D | — | — |
| 6EM5 | State D architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of nucleolar… | electron microscopy | D | — | — |
| 7NAC | State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model | electron microscopy | D | — | — |
| 7OHP | Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL25 expression shut… | electron microscopy | D | — | 1 (best 0.84) |
| 7OHR | Nog1-TAP associated immature ribosomal particle population E from S. cerevisiae | electron microscopy | D | — | 2 (best 0.86) |
| 7OHS | Nog1-TAP associated immature ribosomal particle population F from S. cerevisiae | electron microscopy | D | — | 2 (best 0.88) |
| 7OHX | Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL34 expression shut… | electron microscopy | D | — | 2 (best 0.88) |
| 7R7A | State E1 nucleolar 60S ribosome biogenesis intermediate - Composite model | electron microscopy | D | — | 2 (best 0.89) |
| 8E5T | Yeast co-transcriptional Noc1-Noc2 RNP assembly checkpoint intermediate | electron microscopy | p | — | 3 (best 0.78) |
| 8V83 | 60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map) | electron microscopy | D | — | 3 (best 0.87) |
| 8V84 | 60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map) | electron microscopy | D | — | 2 (best 0.89) |
| Q03532 | AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase HAS1 (Q03532) | predicted | A | — | — |
Experiment against prediction
- 6EM5 chain D against the predicted model Q03532: TM-score 0.95, RMSD 1.29 Å
- 6EM5 chain D against the predicted model Q03532: TM-score 0.95, RMSD 1.29 Å
- 6ELZ chain D against the predicted model Q03532: TM-score 0.95, RMSD 1.29 Å
- 6EM4 chain D against the predicted model Q03532: TM-score 0.95, RMSD 1.26 Å
- 6EM3 chain D against the predicted model Q03532: TM-score 0.95, RMSD 1.26 Å
- 6EM3 chain D against the predicted model Q03532: TM-score 0.95, RMSD 1.26 Å
- 7OHP chain D against the predicted model Q03532: TM-score 0.93, RMSD 1.48 Å
- 7OHX chain D against the predicted model Q03532: TM-score 0.64, RMSD 3.86 Å
- 8V83 chain D against the predicted model Q03532: TM-score 0.64, RMSD 3.84 Å
- 8V84 chain D against the predicted model Q03532: TM-score 0.64, RMSD 3.93 Å
Elsewhere
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