UniProt Q02RL6
tRNA (guanine-N(1)-)-methyltransferase (Q02RL6)
tRNA (guanine-N(1)-)-methyltransferase (UniProt Q02RL6), EC 2.1.1.228: 13 experimental structures on GenesisL1, 9 ligands bound, 18 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q02RL6
- Protein
- tRNA (guanine-N(1)-)-methyltransferase
- EC
- 2.1.1.228
- Experimental structures
- 13
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 18 · 5 records with a druggable one
Structures
13 records of Q02RL6 in the MolNFT archive: 13 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5WYQ | Crystal structure and catalytic mechanism of the essential M1G37 tRNA methyltransferase trmd from… | x-ray diffraction | A, B | — | — |
| 5WYR | Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from… | x-ray diffraction | A, B | SFG | 4 (best 0.80) |
| 5WYR | Crystal structure and catalytic mechanism of the essential M1G37 tRNA methyltransferase trmd from… | x-ray diffraction | A, B | — | — |
| 5ZHM | Crystal structure of trmd from pseudomonas aeruginosa in complex with active-site inhibitor | x-ray diffraction | A, B | 9D3 | — |
| 5ZHN | Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor | x-ray diffraction | A, B | 9D0 | 3 (best 0.72) |
| 5ZHN | Crystal structure of trmd from pseudomonas aeruginosa in complex with active-site inhibitor | x-ray diffraction | A, B | 9D0 | — |
| 6AFK | Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor | x-ray diffraction | A, B | SAM, 9WO | 4 (best 0.81) |
| 6AFK | Crystal structure of trmd from pseudomonas aeruginosa in complex with active-site inhibitor | x-ray diffraction | A, B | 9WO | — |
| 6JKI | Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from… | x-ray diffraction | A, B | SFG, MN, NA | 4 (best 0.74) |
| 6JKI | Crystal structure and catalytic mechanism of the essential M1G37 tRNA methyltransferase trmd from… | x-ray diffraction | A, B | MN, NA | — |
| 6JOE | Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor | x-ray diffraction | A, B | BWR, PO4, SAM | 3 (best 0.75) |
| 6JOE | Crystal structure of trmd from pseudomonas aeruginosa in complex with active-site inhibitor | x-ray diffraction | A, B | BWR, PO4 | — |
| Q02RL6 | AlphaFold monomer V2.0 prediction for tRNA (guanine-N(1)-)-methyltransferase (Q02RL6) | — | — | — |
Ligands
- 9D0 · N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide · in 2 records
- 9WO · N-{(3S)-1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl}-1H-indole-2-carboxamide · in 2 records
- BWR · ~{N}-[[4-[(4-azanylpiperidin-1-yl) methyl]phenyl]methyl]-4-oxidanylidene-3~{H}-thieno[2, 3-d]pyrimidine-5-carboxamide · in 2 records
- MN · Manganese (II) ion · in 2 records
- NA · Sodium ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- SAM · S-adenosylmethionine · in 2 records
- SFG · Sinefungin · in 2 records
- 9D3 · N-({4-[(diethylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide · in 1 record
Elsewhere
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