UniProt Q02218
2-oxoglutarate dehydrogenase, mitochondrial (Q02218)
2-oxoglutarate dehydrogenase, mitochondrial (UniProt Q02218), EC 1.2.4.2: 4 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q02218
- Protein
- 2-oxoglutarate dehydrogenase, mitochondrial
- EC
- 1.2.4.2
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 35 · 2 records with a druggable one
Structures
5 records of Q02218 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3ERY | Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel… | x-ray diffraction | P, Q | — | — |
| 3ERY | Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel… | x-ray diffraction | P, Q | — | — |
| 7WGR | Cryo-electron microscopic structure of the 2-oxoglutarate dehydrogenase (E1) component of the human… | electron microscopy | A, B | CA, MG, TPP | 20 (best 0.90) |
| 7WGR | Cryo-electron microscopic structure of the 2-oxoglutarate dehydrogenase (E1) component of the human… | electron microscopy | A, B | CA, MG, TPP | — |
| Q02218 | AlphaFold monomer V2.0 prediction for 2-oxoglutarate dehydrogenase, mitochondrial (Q02218) | predicted | A | — | 15 (best 0.63) |
Ligands
Experiment against prediction
- 7WGR chain A against the predicted model Q02218: TM-score 0.98, RMSD 1.27 Å
- 7WGR chain A against the predicted model Q02218: TM-score 0.98, RMSD 1.27 Å
- 3ERY chain P against the predicted model Q02218: TM-score 0.35, RMSD 1.20 Å
- 3ERY chain P against the predicted model Q02218: TM-score 0.35, RMSD 1.20 Å
Elsewhere
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