UniProt Q01939
26S proteasome regulatory subunit 8 homolog (Q01939)
26S proteasome regulatory subunit 8 homolog (UniProt Q01939): 38 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 77 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q01939
- Protein
- 26S proteasome regulatory subunit 8 homolog
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 77 · 18 records with a druggable one
Structures
39 records of Q01939 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JCO | Structure of yeast 26S proteasome in M1 state derived from Titan dataset | electron microscopy | J | — | — |
| 3JCP | Structure of yeast 26S proteasome in M2 state derived from Titan dataset | electron microscopy | J | — | — |
| 4CR2 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | J | — | — |
| 4CR2 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | J | — | — |
| 4CR3 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | J | — | — |
| 4CR3 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | J | — | — |
| 4CR4 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | J | — | — |
| 4CR4 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | J | — | — |
| 5A5B | Structure of the 26S proteasome-Ubp6 complex | electron microscopy | J | — | — |
| 5A5B | Structure of the 26S proteasome-UBP6 complex | electron microscopy | J | — | — |
| 5MP9 | 26S proteasome in presence of ATP (s1) | electron microscopy | J | ATP, ADP, MG | — |
| 5MP9 | 26S proteasome in presence of ATP (S1) | electron microscopy | J | ATP, ADP, MG | — |
| 5MPA | 26S proteasome in presence of ATP (s2) | electron microscopy | J | ATP, MG, ADP | 2 (best 0.80) |
| 5MPA | 26S proteasome in presence of ATP (S2) | electron microscopy | J | ATP, ADP, MG | — |
| 5MPB | 26S proteasome in presence of AMP-PNP (s3) | electron microscopy | J | ANP, MG | 4 (best 0.83) |
| 5MPC | 26S proteasome in presence of BeFx (s4) | electron microscopy | J | ATP, MG | — |
| 5WVI | The resting state of yeast proteasome | electron microscopy | J | — | — |
| 5WVK | Yeast proteasome-ADP-AlFx | electron microscopy | J | — | 3 (best 0.82) |
| 6EF0 | Yeast 26S proteasome bound to ubiquitinated substrate (1D* motor state) | electron microscopy | J | ATP | 6 (best 0.84) |
| 6EF0 | Yeast 26S proteasome bound to ubiquitinated substrate (1D* motor state) | electron microscopy | J | ATP | — |
| 6EF1 | Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state) | electron microscopy | J | ATP | 7 (best 0.90) |
| 6EF1 | Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state) | electron microscopy | J | ATP | — |
| 6EF2 | Yeast 26S proteasome bound to ubiquitinated substrate (5T motor state) | electron microscopy | J | ATP | 5 (best 0.81) |
| 6EF2 | Yeast 26S proteasome bound to ubiquitinated substrate (5T motor state) | electron microscopy | J | ATP | — |
| 6EF3 | Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state) | electron microscopy | J | ATP | 5 (best 0.83) |
| 6EF3 | Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state) | electron microscopy | J | ATP | — |
| 6FVT | 26S proteasome, s1 state | electron microscopy | J | ATP, MG, ADP | — |
| 6FVU | 26S proteasome, s2 state | electron microscopy | J | ATP, ADP, MG | 4 (best 0.80) |
| 6FVV | 26S proteasome, s3 state | electron microscopy | J | ATP, MG | 5 (best 0.84) |
| 6FVW | 26S proteasome, s4 state | electron microscopy | J | ATP, MG | 7 (best 0.83) |
| 6FVX | 26S proteasome, s5 state | electron microscopy | J | ATP, ADP, MG | 3 (best 0.83) |
| 6FVY | 26S proteasome, s6 state | electron microscopy | J | ATP, MG | 5 (best 0.80) |
| 6J2C | Yeast proteasome in translocation competent state (C3-a) | electron microscopy | J | — | 4 (best 0.82) |
| 6J2N | yeast proteasome in substrate-processing state (C3-b) | electron microscopy | J | — | 3 (best 0.80) |
| 6J2Q | Yeast proteasome in Ub-accepted state (C1-b) | electron microscopy | J | — | 5 (best 0.87) |
| 6J2X | Yeast proteasome in resting state (C1-a) | electron microscopy | J | — | — |
| 6J30 | yeast proteasome in Ub-engaged state (C2) | electron microscopy | J | — | 4 (best 0.84) |
| 7QO5 | 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state | electron microscopy | J | ATP, MG, ADP | 3 (best 0.83) |
| Q01939 | AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit 8 homolog (Q01939) | predicted | A | — | 2 (best 0.55) |
Ligands
Experiment against prediction
- 6EF2 chain J against the predicted model Q01939: TM-score 0.89, RMSD 1.99 Å
- 6EF2 chain J against the predicted model Q01939: TM-score 0.89, RMSD 1.99 Å
- 6EF0 chain J against the predicted model Q01939: TM-score 0.88, RMSD 1.94 Å
- 6EF0 chain J against the predicted model Q01939: TM-score 0.88, RMSD 1.94 Å
- 6EF1 chain J against the predicted model Q01939: TM-score 0.87, RMSD 2.25 Å
- 6EF1 chain J against the predicted model Q01939: TM-score 0.87, RMSD 2.25 Å
- 4CR4 chain J against the predicted model Q01939: TM-score 0.81, RMSD 3.60 Å
- 4CR4 chain J against the predicted model Q01939: TM-score 0.81, RMSD 3.60 Å
- 6EF3 chain J against the predicted model Q01939: TM-score 0.80, RMSD 3.16 Å
- 6EF3 chain J against the predicted model Q01939: TM-score 0.80, RMSD 3.16 Å
Elsewhere
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