UniProt Q01468
2-hydroxymuconate tautomerase (Q01468)
2-hydroxymuconate tautomerase (UniProt Q01468), EC 5.3.2.6: 22 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q01468
- Protein
- 2-hydroxymuconate tautomerase
- EC
- 5.3.2.6
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 5
Structures
23 records of Q01468 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BJP | Crystal structure of 4-oxalocrotonate tautomerase inactivated by 2-oxo-3-pentynoate at 2.4… | x-ray diffraction | A, B, C, D, E | — | — |
| 1BJP | Crystal structure of 4-oxalocrotonate tautomerase inactivated by 2- oxo-3-pentynoate at 2.4… | x-ray diffraction | A, B, C, D, E | — | — |
| 2FM7 | Evolution of Enzymatic Activity in the Tautomerase Superfamily: Mechanistic and Structural… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2FM7 | Evolution of enzymatic activity in the tautomerase superfamily: mechanistic and structural… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4OTA | 4-oxalocrotonate tautomerase observed as an octodecamer, orthorhombic crystal form | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R | — | — |
| 4OTA | 4-oxalocrotonate tautomerase observed as an octodecamer, orthorhombic crystal form | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R | — | — |
| 4OTB | 4-oxalocrotonate tautomerase observed as an octodecamer, rhombohedral crystal form | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4OTB | 4-oxalocrotonate tautomerase observed as an octodecamer, rhombohedral crystal form | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4OTC | 4-oxalocrotonate tautomerase observed as an octodecamer, trigonal crystal form | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 4OTC | 4-oxalocrotonate tautomerase observed as an octodecamer, trigonal crystal form | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 4X19 | Crystal structure of native 4-OT from Pseudomonas putida mt-2 at 1.94 Angstrom | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d | — | — |
| 4X19 | Crystal structure of native 4-ot from pseudomonas putida mt-2 at 1.94 ångström | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d | — | — |
| 4X1C | Crystal structure of 4-OT from Pseudomonas putida mt-2 with an enamine adduct on the N-terminal… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 4X1C | Crystal structure of 4-ot from pseudomonas putida mt-2 with an enamine adduct on the N-terminal… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 5CLN | Crystal structure of a 4-oxalocrotonate tautomerase mutant at 2.7 Angstrom | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 5CLN | Crystal structure of a 4-oxalocrotonate tautomerase mutant at 2.7 ångström | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 5CLO | Crystal structure of a 4-oxalocrotonate tautomerase mutant in complex with nitrostyrene at 2.3… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R | — | — |
| 5TIG | Crystal structure of 4-oxalocrotonate tautomerase inactivated by brhpd | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d | 7DH | — |
| 6BGN | Crystal structure of 4-oxalocrotonate tautomerase after incubation with… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | 6Y5, NO3 | — |
| 6FPS | Crystal structure of 4-oxalocrotonate tautomerase triple mutant L8Y/M45Y/F50A | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R | PO4 | — |
| 6GHW | Substituting the prolines of 4-oxalocrotonate tautomerase with non-canonical analogue… | x-ray diffraction | A, B, C | CA | — |
| 6GHW | Substituting the prolines of 4-oxalocrotonate tautomerase with non- canonical analogue… | x-ray diffraction | A, B, C | CA | — |
| Q01468 | AlphaFold monomer V2.0 prediction for 2-hydroxymuconate tautomerase (Q01468) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1BJP chain D against the predicted model Q01468: TM-score 0.96, RMSD 0.51 Å
- 1BJP chain D against the predicted model Q01468: TM-score 0.96, RMSD 0.51 Å
- 6BGN chain A against the predicted model Q01468: TM-score 0.96, RMSD 0.51 Å
- 1BJP chain C against the predicted model Q01468: TM-score 0.96, RMSD 0.53 Å
- 1BJP chain C against the predicted model Q01468: TM-score 0.96, RMSD 0.53 Å
- 5CLN chain I against the predicted model Q01468: TM-score 0.96, RMSD 0.55 Å
- 5CLN chain I against the predicted model Q01468: TM-score 0.96, RMSD 0.55 Å
- 5TIG chain E against the predicted model Q01468: TM-score 0.95, RMSD 0.59 Å
- 1BJP chain B against the predicted model Q01468: TM-score 0.95, RMSD 0.82 Å
- 1BJP chain B against the predicted model Q01468: TM-score 0.95, RMSD 0.82 Å
Elsewhere
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