UniProt Q00535
Cyclin-dependent-like kinase 5 (Q00535)
Cyclin-dependent-like kinase 5 (UniProt Q00535), EC 2.7.11.1: 19 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q00535
- Protein
- Cyclin-dependent-like kinase 5
- EC
- 2.7.11.1
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 24 · 2 records with a druggable one
Structures
20 records of Q00535 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1H4L | Structure and regulation of the CDK5-p25(nck5a) complex | x-ray diffraction | A, B | — | — |
| 1H4L | Structure and regulation of the CDK5-P25(NCK5A) complex | x-ray diffraction | A, B | — | — |
| 1UNG | Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin. | x-ray diffraction | A, B | — | — |
| 1UNG | Structural mechanism for the inhibition of CDK5-P25 by roscovitine, aloisine and indirubin. | x-ray diffraction | A, B | — | — |
| 1UNH | Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin. | x-ray diffraction | A, B | — | — |
| 1UNH | Structural mechanism for the inhibition of CDK5-P25 by roscovitine, aloisine and indirubin. | x-ray diffraction | A, B | — | — |
| 1UNL | Structural mechanism for the inhibition of CD5-p25 from the roscovitine, aloisine and indirubin. | x-ray diffraction | A, B | — | — |
| 1UNL | Structural mechanism for the inhibition of CD5-P25 from the roscovitine, aloisine and indirubin. | x-ray diffraction | A, B | — | — |
| 3O0G | Crystal Structure of Cdk5:p25 in complex with an ATP analogue | x-ray diffraction | A, B | — | — |
| 3O0G | Crystal structure of CDK5:P25 in complex with an ATP analogue | x-ray diffraction | A, B | — | — |
| 4AU8 | Crystal structure of compound 4a in complex with cdk5, showing an unusual binding mode to the hinge… | x-ray diffraction | A, B | — | — |
| 4AU8 | Crystal structure of compound 4A in complex with CDK5, showing an unusual binding mode to the hinge… | x-ray diffraction | A, B | — | — |
| 7VDP | The structure of cyclin-dependent kinase 5 (CDK5) in complex with P25 and compound 1 | x-ray diffraction | A, B | 65L, CL | — |
| 7VDQ | The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 7 | x-ray diffraction | A, B | 64V | 13 (best 0.77) |
| 7VDQ | The structure of cyclin-dependent kinase 5 (CDK5) in complex with P25 and compound 7 | x-ray diffraction | A, B | 64V | — |
| 7VDR | The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 13 | x-ray diffraction | A, B | 63I | 11 (best 0.75) |
| 7VDR | The structure of cyclin-dependent kinase 5 (CDK5) in complex with P25 and compound 13 | x-ray diffraction | A, B | 63I | — |
| 7VDS | The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 24 | x-ray diffraction | A, B | 61U, CL | — |
| 7VDS | The structure of cyclin-dependent kinase 5 (CDK5) in complex with P25 and compound 24 | x-ray diffraction | A, B | 61U, CL | — |
| Q00535 | AlphaFold monomer V2.0 prediction for cyclin-dependent-like kinase 5 (Q00535) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 3 records
- 61U · 5-fluoranyl-4-[[2-[(1R)-1-(1-methylpiperidin-4-yl)-1-oxidanyl-ethyl]-1,6-naphthyridin-7-yl]amino]-2-morpholin-4-yl-benzenecarbonitrile · in 2 records
- 63I · (1R)-1-[7-[(2-fluoranyl-4-pyrazol-1-yl-phenyl)amino]-1, 6-naphthyridin-2-yl]-1-(1-methylpiperidin-4-yl)ethanol · in 2 records
- 64V · 2-[[7-[[2-fluoranyl-4-[3-(hydroxymethyl)pyrazol-1-yl]phenyl]amino]-1,6-naphthyridin-2-yl]-(1-methylpiperidin-4-yl)amino]ethanoic acid · in 2 records
- 65L · [1-[3-fluoranyl-4-[(2-piperidin-4-yloxy-1,6-naphthyridin-7-yl)amino]phenyl]pyrazol-3-yl]methanol · in 1 record
Experiment against prediction
- 7VDR chain B against the predicted model Q00535: TM-score 0.98, RMSD 0.91 Å
- 7VDR chain B against the predicted model Q00535: TM-score 0.98, RMSD 0.91 Å
- 1H4L chain B against the predicted model Q00535: TM-score 0.98, RMSD 0.97 Å
- 1H4L chain B against the predicted model Q00535: TM-score 0.98, RMSD 0.97 Å
- 1UNH chain B against the predicted model Q00535: TM-score 0.98, RMSD 0.98 Å
- 1UNH chain B against the predicted model Q00535: TM-score 0.98, RMSD 0.98 Å
- 3O0G chain B against the predicted model Q00535: TM-score 0.98, RMSD 0.82 Å
- 3O0G chain B against the predicted model Q00535: TM-score 0.98, RMSD 0.82 Å
- 1H4L chain A against the predicted model Q00535: TM-score 0.98, RMSD 1.02 Å
- 1H4L chain A against the predicted model Q00535: TM-score 0.98, RMSD 1.02 Å
Elsewhere
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