UniProt P9WPP3
Methyl-branched lipid omega-hydroxylase (P9WPP3)
Methyl-branched lipid omega-hydroxylase (UniProt P9WPP3), EC 1.14.15.14, 1.14.15.28: 9 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 9 pockets. Binding sites, druggability and experiment against…
- UniProt
- P9WPP3
- Protein
- Methyl-branched lipid omega-hydroxylase
- EC
- 1.14.15.14, 1.14.15.28
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 9 · 2 records with a druggable one
Structures
10 records of P9WPP3 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6T0F | Crystal structure of CYP124 in complex with cholest-4-en-3-one | x-ray diffraction | A, B, C, D | HEM, K2B | — |
| 6T0F | Crystal structure of CYP124 in complex with cholest-4-en-3-one | x-ray diffraction | A, B, C, D | HEM, K2B | — |
| 6T0G | Crystal structure of CYP124 in complex with vitamin D3 | x-ray diffraction | A | HEM, VD3, MG | 4 (best 0.89) |
| 6T0G | Crystal structure of CYP124 in complex with vitamin D3 | x-ray diffraction | A | HEM, VD3 | — |
| 6T0H | Crystal structure of CYP124 in complex with 1-alpha-hydroxy-vitamin D3 | x-ray diffraction | A | HEM, M9B, CL | — |
| 6T0J | Crystal structure of CYP124 in complex with SQ109 | x-ray diffraction | A | HEM, RWZ, MG | 5 (best 0.89) |
| 6T0J | Crystal structure of CYP124 in complex with SQ109 | x-ray diffraction | A | HEM, RWZ | — |
| 6T0K | Crystal structure of CYP124 in complex with inhibitor carbethoxyhexyl imidazole | x-ray diffraction | A | HEM, M65, CL | — |
| 6T0L | Crystal structure of CYP124 in complex with inhibitor compound 5' | x-ray diffraction | A | HEM, M8N, CL | — |
| P9WPP3 | AlphaFold monomer V2.0 prediction for methyl-branched lipid omega- hydroxylase (P9WPP3) | predicted | A | — | — |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 9 records
- CL · Chloride ion · in 3 records
- K2B · (8alpha,9beta)-cholest-4-en-3-one · in 2 records
- MG · Magnesium ion · in 2 records
- RWZ · N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R, 7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine · in 2 records
- VD3 · (1S,3Z)-3-[(2E)-2-[(1r,3ar,7as)-7A-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3A,5,6,7-hexahydro-1H-inden-4-ylidene]ethyli dene]-4-methylidene-cyclohexan-1-ol · in 2 records
- M65 · Ethyl 7-imidazol-1-ylheptanoate · in 1 record
- M8N · ~{N}-[[[2-methyl-4-(3-methylbutyl) phenyl]amino]methyl]hydroxylamine · in 1 record
- M9B · 1-alpha-hydroxy-vitamin D3 · in 1 record
Experiment against prediction
- 6T0L chain A against the predicted model P9WPP3: TM-score 0.98, RMSD 1.00 Å
- 6T0F chain D against the predicted model P9WPP3: TM-score 0.98, RMSD 1.04 Å
- 6T0F chain D against the predicted model P9WPP3: TM-score 0.98, RMSD 1.04 Å
- 6T0F chain A against the predicted model P9WPP3: TM-score 0.98, RMSD 1.04 Å
- 6T0F chain A against the predicted model P9WPP3: TM-score 0.98, RMSD 1.04 Å
- 6T0G chain A against the predicted model P9WPP3: TM-score 0.98, RMSD 1.10 Å
- 6T0G chain A against the predicted model P9WPP3: TM-score 0.98, RMSD 1.10 Å
- 6T0F chain C against the predicted model P9WPP3: TM-score 0.98, RMSD 1.22 Å
- 6T0F chain C against the predicted model P9WPP3: TM-score 0.98, RMSD 1.22 Å
- 6T0F chain B against the predicted model P9WPP3: TM-score 0.98, RMSD 1.22 Å
Elsewhere
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