UniProt P9WPC9
ATP-dependent Clp protease ATP-binding subunit ClpC1 (P9WPC9)
ATP-dependent Clp protease ATP-binding subunit ClpC1 (UniProt P9WPC9), EC 3.4.-.-: 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 40 pockets. Binding sites, druggability and experiment against…
- UniProt
- P9WPC9
- Protein
- ATP-dependent Clp protease ATP-binding subunit ClpC1
- EC
- 3.4.-.-
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 40 · 2 records with a druggable one
Structures
9 records of P9WPC9 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6CN8 | High-resolution structure of ClpC1-NTD binding to Rufomycin-I | x-ray diffraction | A | PO4, CL, NA | — |
| 6CN8 | High-resolution structure of CLPC1-ntd binding to rufomycin-I | x-ray diffraction | A | PO4, CL, NA | — |
| 6PBA | Structure of CLPC1-ntd | x-ray diffraction | A | — | — |
| 6PBQ | Structure of CLPC1-ntd | x-ray diffraction | A | PO4 | — |
| 6PBS | Structure of CLPC1-ntd in complex with ecumicin | x-ray diffraction | A, I, C, W, Y, e, B, G, K, M, O, T | O7D | — |
| 8A8V | Mycobacterium tuberculosis ClpC1 hexamer structure bound to the natural product antibiotic… | electron microscopy | A, B, C, D, E, F | ADP | 20 (best 0.83) |
| 8A8W | Mycobacterium tuberculosis ClpC1 hexamer structure bound to the natural product antibiotic Ecumycin… | electron microscopy | A, B, C, D, E, F | ADP | 20 (best 0.86) |
| 8B9U | Structure of ClpC1 NTD from Mycobacterium tuberculosis | x-ray diffraction | A, B | — | — |
| P9WPC9 | AlphaFold monomer V2.0 prediction for ATP-dependent clp protease ATP- binding subunit CLPC1 (P9WPC9) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8B9U chain A against the predicted model P9WPC9: TM-score 0.98, RMSD 0.78 Å
- 6CN8 chain A against the predicted model P9WPC9: TM-score 0.96, RMSD 1.30 Å
- 6CN8 chain A against the predicted model P9WPC9: TM-score 0.96, RMSD 1.30 Å
- 8B9U chain B against the predicted model P9WPC9: TM-score 0.96, RMSD 1.16 Å
- 8A8V chain B against the predicted model P9WPC9: TM-score 0.93, RMSD 2.43 Å
- 8A8W chain B against the predicted model P9WPC9: TM-score 0.92, RMSD 2.51 Å
- 8A8V chain E against the predicted model P9WPC9: TM-score 0.91, RMSD 2.92 Å
- 8A8W chain E against the predicted model P9WPC9: TM-score 0.90, RMSD 2.95 Å
- 8A8V chain D against the predicted model P9WPC9: TM-score 0.90, RMSD 3.09 Å
- 8A8V chain C against the predicted model P9WPC9: TM-score 0.90, RMSD 3.07 Å
Elsewhere
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