UniProt P9WNV1
DNA ligase A (P9WNV1)
DNA ligase A (UniProt P9WNV1), EC 6.5.1.2: 14 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P9WNV1
- Protein
- DNA ligase A
- EC
- 6.5.1.2
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 10 · 2 records with a druggable one
Structures
15 records of P9WNV1 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6KDU | Structural basis for domain rotation during adenylation of active site K123 and fragment library… | x-ray diffraction | A | AMP, NMN, SO4 | — |
| 6KDU | Structural basis for domain rotation during adenylation of active site K123 and fragment library… | x-ray diffraction | A | AMP, NMN, SO4 | — |
| 6KJM | Structural basis for domain rotation during adenylation of active site K123 and fragment library… | x-ray diffraction | A | NMN, AMP, SO4 | — |
| 6KJM | Structural basis for domain rotation during adenylation of active site K123 and fragment library… | x-ray diffraction | A | NMN, AMP, SO4 | — |
| 6KKV | Structural basis for domain rotation during adenylation of active site K123 and fragment library… | x-ray diffraction | A | DKR, SO4 | — |
| 6KKV | Structural basis for domain rotation during adenylation of active site K123 and fragment library… | x-ray diffraction | A | DKR, SO4 | — |
| 6KRH | Structural basis for domain rotation during adenylation of active site K123 and fragment library… | x-ray diffraction | A | AMP, NMN, SO4 | — |
| 6KRH | Structural basis for domain rotation during adenylation of active site K123 and fragment library… | x-ray diffraction | A | AMP, NMN, SO4 | — |
| 6KSC | Structural basis for domain rotation during adenylation of active site K123 and fragment library… | x-ray diffraction | A | AMP, SO4 | — |
| 6KSD | Structural basis for domain rotation during adenylation of active site K123 and fragment library… | x-ray diffraction | A | NMN, SO4 | — |
| 6LW8 | Structural basis for domain rotation during adenylation of active site K123 and fragment library… | x-ray diffraction | A | EWO, SO4 | 2 (best 0.71) |
| 6LW8 | Structural basis for domain rotation during adenylation of active site K123 and fragment library… | x-ray diffraction | A | EWO, SO4 | — |
| 7K72 | Structure of DNA ligase A from Mycobacterium tuberculosis bound to NAD | x-ray diffraction | A, B, C, D | NAD, MG, CA | 8 (best 0.84) |
| 7K72 | Structure of DNA ligase a from mycobacterium tuberculosis bound to NAD | x-ray diffraction | A, B, C, D | NAD, MG, CA | — |
| P9WNV1 | AlphaFold monomer V2.0 prediction for DNA ligase a (P9WNV1) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 12 records
- AMP · Adenosine monophosphate · in 7 records
- NMN · Beta-nicotinamide ribose monophosphate · in 7 records
- CA · Calcium ion · in 2 records
- DKR · N-[(4-methylphenyl)methyl]-1H-pyrrole-2-carboxamide · in 2 records
- EWO · (4R)-4-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine · in 2 records
- MG · Magnesium ion · in 2 records
- NAD · Nicotinamide-adenine-dinucleotide · in 2 records
Experiment against prediction
- 6KRH chain A against the predicted model P9WNV1: TM-score 0.98, RMSD 0.95 Å
- 6KRH chain A against the predicted model P9WNV1: TM-score 0.98, RMSD 0.95 Å
- 6LW8 chain A against the predicted model P9WNV1: TM-score 0.98, RMSD 0.94 Å
- 6LW8 chain A against the predicted model P9WNV1: TM-score 0.98, RMSD 0.94 Å
- 6KJM chain A against the predicted model P9WNV1: TM-score 0.98, RMSD 0.99 Å
- 6KJM chain A against the predicted model P9WNV1: TM-score 0.98, RMSD 0.99 Å
- 6KDU chain A against the predicted model P9WNV1: TM-score 0.98, RMSD 1.15 Å
- 6KDU chain A against the predicted model P9WNV1: TM-score 0.98, RMSD 1.15 Å
- 6KSD chain A against the predicted model P9WNV1: TM-score 0.98, RMSD 1.06 Å
- 6KKV chain A against the predicted model P9WNV1: TM-score 0.98, RMSD 1.20 Å
Elsewhere
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