UniProt P9WK17
Malate synthase G (P9WK17)
Malate synthase G (UniProt P9WK17), EC 2.3.3.9: 43 experimental structures and 1 predicted model on GenesisL1, 26 ligands bound, 249 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P9WK17
- Protein
- Malate synthase G
- EC
- 2.3.3.9
- Experimental structures
- 43
- Predicted models
- 1
- Ligands
- 26
- Pockets
- 249 · 43 records with a druggable one
Structures
44 records of P9WK17 in the MolNFT archive: 43 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5C7V | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, PYC | 6 (best 0.71) |
| 5C7V | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, PYC | 6 (best 0.71) |
| 5C9R | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4YZ | 8 (best 0.74) |
| 5C9R | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4YZ | 8 (best 0.74) |
| 5C9U | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4Z1 | 8 (best 0.75) |
| 5C9U | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4Z1 | 8 (best 0.75) |
| 5C9W | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4Z3 | 7 (best 0.74) |
| 5C9W | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4Z3 | 7 (best 0.74) |
| 5C9X | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4Z4 | 8 (best 0.76) |
| 5C9X | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4Z4 | 8 (best 0.76) |
| 5CAH | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4ZA | 3 (best 0.74) |
| 5CAK | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4Z9 | 7 (best 0.74) |
| 5CBB | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4ZF | 4 (best 0.74) |
| 5CBB | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4ZF | 4 (best 0.74) |
| 5CBI | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4ZC | 5 (best 0.74) |
| 5CBJ | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4ZD | 4 (best 0.75) |
| 5CC3 | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4ZU | 6 (best 0.72) |
| 5CC5 | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, GLV, ICO | 6 (best 0.72) |
| 5CC5 | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, GLV, ICO | 6 (best 0.72) |
| 5CC6 | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4ZV | 3 (best 0.69) |
| 5CC6 | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4ZV | 3 (best 0.69) |
| 5CC7 | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 1F1 | 6 (best 0.73) |
| 5CC7 | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 1F1 | 6 (best 0.73) |
| 5CCZ | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | 50C, MG | 3 (best 0.75) |
| 5CEW | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 6MW | 6 (best 0.75) |
| 5CJM | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4WL | 3 (best 0.75) |
| 5CJN | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 52F | 8 (best 0.72) |
| 5DRC | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 5ER | 7 (best 0.70) |
| 5DRC | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 5ER | 7 (best 0.70) |
| 5DX7 | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 5H6 | 5 (best 0.72) |
| 5DX7 | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 5H6 | 5 (best 0.72) |
| 5E9X | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 5LA | 2 (best 0.72) |
| 5E9X | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 5LA | 2 (best 0.72) |
| 5ECV | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 5M2 | 5 (best 0.70) |
| 5ECV | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 5M2 | 5 (best 0.70) |
| 5H8M | Crystal structure of Mycobacterium tuberculosis malate synthase C619A, G459A mutant in complex with… | x-ray diffraction | A | MG, LMR | 5 (best 0.72) |
| 5H8M | Crystal structure of mycobacterium tuberculosis malate synthase C619A, G459A mutant in complex with… | x-ray diffraction | A | MG, LMR | 5 (best 0.72) |
| 5H8P | Crystal structure of Mycobacterium tuberculosis malate synthase in apo form | x-ray diffraction | A | — | 2 (best 0.74) |
| 5H8P | Crystal structure of mycobacterium tuberculosis malate synthase in apo form | x-ray diffraction | A | — | 2 (best 0.74) |
| 5H8U | Crystal structure of mycobacterium tuberculosis wild-type malate synthase in complex with product… | x-ray diffraction | A, B | MG, LMR, GLV | 13 (best 0.69) |
| 5H8U | Crystal structure of mycobacterium tuberculosis wild-type malate synthase in complex with product… | x-ray diffraction | A, B | MG, LMR, GLV | 13 (best 0.69) |
| 5T8G | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4Z0 | 7 (best 0.68) |
| 5T8G | Crystal structure of mycobacterium tuberculosis malate synthase in complex with… | x-ray diffraction | A | MG, 4Z0 | 7 (best 0.68) |
| P9WK17 | AlphaFold monomer V2.0 prediction for malate synthase G (P9WK17) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 41 records
- GLV · Glyoxylic acid · in 4 records
- LMR · (2S)-2-hydroxybutanedioic acid · in 4 records
- 1F1 · 1H-indole-6-carboxylic acid · in 2 records
- 4YZ · 3-[(4-chlorophenyl)sulfanyl]propanoic acid · in 2 records
- 4Z0 · (3E)-2-oxo-4-[(thiophen-2-ylcarbonyl)oxy]but-3-enoic acid · in 2 records
- 4Z1 · [2-(2,4-dichlorophenyl)hydrazinyl](oxo)acetic acid · in 2 records
- 4Z3 · (2E)-N-(2-bromophenyl)-2-(hydroxyimino)acetamide · in 2 records
- 4Z4 · 2,4-dichloro-5-fluorobenzoic acid · in 2 records
- 4ZF · (5E)-5-(3H-indol-3-ylidene)-2,5-dihydro-1H-pyrazole-3-carboxylic acid · in 2 records
- 4ZV · 1H-indole-5-carboxylic acid · in 2 records
- 5ER · (2Z)-2-hydroxy-4-(1H-indol-3-yl)-4-oxobut-2-enoic acid · in 2 records
- 5H6 · 5-(5-chlorothiophen-2-yl)-1,2-oxazole-3-carboxylic acid · in 2 records
- 5LA · 2-chloranyl-6~{H}-thieno[2,3-b]pyrrole-5-carboxylic acid · in 2 records
- 5M2 · (~{Z})-4-(4-methyl-1~{H}-indol-5-yl)-2-oxidanyl-4-oxidanylidene-but-2-enoic acid · in 2 records
- ICO · 1H-indole-3-carboxylic acid · in 2 records
- PYC · Pyrrole-2-carboxylate · in 2 records
- 4WL · 4H-thieno[3,2-b]pyrole-5-carboxylic acid · in 1 record
- 4Z9 · (2R)-2-hydroxy-3-(1H-indol-3-yl)propanoic acid · in 1 record
- 4ZA · 6H-thieno[2,3-b]pyrrole-5-carboxylic acid · in 1 record
- 4ZC · 5-chloro-2-hydroxybenzonitrile · in 1 record
- 4ZD · (2E)-3-(phenylsulfanyl)prop-2-enoic acid · in 1 record
- 4ZU · 6-bromanyl-1H-indole-2-carboxylic acid · in 1 record
- 50C · 3-(4-fluorophenyl)-4-methyl-1H-pyrazol-5-amine · in 1 record
- 52F · 3-(3-oxo-3,4-dihydroquinoxalin-2-yl)propanoic acid · in 1 record
- 6MW · (2S,4S)-2-(pyridin-4-yl)-1,3-thiazolidine-4-carboxylic acid · in 1 record
Experiment against prediction
- 5H8P chain A against the predicted model P9WK17: TM-score 1.00, RMSD 0.55 Å
- 5H8P chain A against the predicted model P9WK17: TM-score 1.00, RMSD 0.55 Å
- 5CCZ chain A against the predicted model P9WK17: TM-score 1.00, RMSD 0.56 Å
- 5CBJ chain A against the predicted model P9WK17: TM-score 1.00, RMSD 0.58 Å
- 5H8M chain A against the predicted model P9WK17: TM-score 1.00, RMSD 0.58 Å
- 5H8M chain A against the predicted model P9WK17: TM-score 1.00, RMSD 0.58 Å
- 5CJN chain A against the predicted model P9WK17: TM-score 1.00, RMSD 0.60 Å
- 5CC7 chain A against the predicted model P9WK17: TM-score 1.00, RMSD 0.61 Å
- 5CC7 chain A against the predicted model P9WK17: TM-score 1.00, RMSD 0.61 Å
- 5C9X chain A against the predicted model P9WK17: TM-score 1.00, RMSD 0.62 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.