UniProt P9WFU3
Phenylalanine--tRNA ligase alpha subunit (P9WFU3)
Phenylalanine--tRNA ligase alpha subunit (UniProt P9WFU3), EC 6.1.1.20: 14 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 68 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P9WFU3
- Protein
- Phenylalanine--tRNA ligase alpha subunit
- EC
- 6.1.1.20
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 68 · 8 records with a druggable one
Structures
15 records of P9WFU3 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7DAW | Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase | x-ray diffraction | A | SO4 | 7 (best 0.80) |
| 7DAW | Crystal structure of mycobacterium tuberculosis phenylalanyl-tRNA synthetase | x-ray diffraction | A | SO4 | — |
| 7DB7 | Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with… | x-ray diffraction | A | H2L, SO4 | 7 (best 0.78) |
| 7DB7 | Crystal structure of mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with… | x-ray diffraction | A | H2L, SO4 | — |
| 7DB8 | Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with… | x-ray diffraction | A | SO4, H2R | 6 (best 0.80) |
| 7DB8 | Crystal structure of mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with… | x-ray diffraction | A | SO4, H2R | — |
| 7K98 | Preaminoacylation complex of M. tuberculosis PheRS with cognate precursor tRNA and… | x-ray diffraction | A, D | W5Y, MG | 14 (best 0.87) |
| 7K98 | Preaminoacylation complex of M. tuberculosis phers with cognate precursor tRNA and… | x-ray diffraction | A, D | MG | — |
| 7K9M | Crystal structure of the complex of M. tuberculosis PheRS with cognate precursor tRNA and… | x-ray diffraction | A | W5Y, MG | 8 (best 0.79) |
| 7K9M | Crystal structure of the complex of M. tuberculosis phers with cognate precursor tRNA and… | x-ray diffraction | A | MG | — |
| 7KA0 | Crystal structure of the complex of M. tuberculosis PheRS with cognate precursor tRNA and… | x-ray diffraction | A, D | PHE, MG, SO4, K | 15 (best 0.87) |
| 7KA0 | Crystal structure of the complex of M. tuberculosis phers with cognate precursor tRNA and… | x-ray diffraction | A, D | MG, SO4, K | — |
| 7KAB | M. tuberculosis PheRS complex with cognate precursor tRNA and phenylalanine | x-ray diffraction | A | PHE, MG, SO4 | 9 (best 0.78) |
| 7KAB | M. tuberculosis phers complex with cognate precursor tRNA and phenylalanine | x-ray diffraction | A | MG, SO4 | — |
| P9WFU3 | AlphaFold monomer V2.0 prediction for phenylalanine--tRNA ligase alpha subunit (P9WFU3) | predicted | A | — | 2 (best 0.69) |
Ligands
- SO4 · Sulfate ion · in 10 records
- MG · Magnesium ion · in 8 records
- H2L · 1-[3-[2-(1H-indol-3-yl)ethylsulfamoyl]phenyl]-3-(1,3-thiazol-2-yl)urea · in 2 records
- H2R · N-pyridin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]piperidine-1-carboxamide · in 2 records
- K · Potassium ion · in 2 records
- PHE · Phenylalanine · in 2 records
- W5Y · 5'-O-(L-phenylalanylsulfamoyl)adenosine · in 2 records
Experiment against prediction
- 7KA0 chain A against the predicted model P9WFU3: TM-score 0.96, RMSD 1.62 Å
- 7KA0 chain A against the predicted model P9WFU3: TM-score 0.95, RMSD 1.62 Å
- 7KAB chain A against the predicted model P9WFU3: TM-score 0.95, RMSD 1.71 Å
- 7DB8 chain A against the predicted model P9WFU3: TM-score 0.95, RMSD 1.62 Å
- 7DB8 chain A against the predicted model P9WFU3: TM-score 0.95, RMSD 1.62 Å
- 7KAB chain A against the predicted model P9WFU3: TM-score 0.95, RMSD 1.71 Å
- 7DAW chain A against the predicted model P9WFU3: TM-score 0.94, RMSD 1.65 Å
- 7DAW chain A against the predicted model P9WFU3: TM-score 0.94, RMSD 1.65 Å
- 7KA0 chain D against the predicted model P9WFU3: TM-score 0.94, RMSD 1.84 Å
- 7K9M chain A against the predicted model P9WFU3: TM-score 0.94, RMSD 1.84 Å
Elsewhere
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