UniProt P9WFK7
N-acetyltransferase Eis (P9WFK7)
N-acetyltransferase Eis (UniProt P9WFK7), EC 2.3.1.-: 46 experimental structures and 1 predicted model on GenesisL1, 35 ligands bound, 64 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P9WFK7
- Protein
- N-acetyltransferase Eis
- EC
- 2.3.1.-
- Experimental structures
- 46
- Predicted models
- 1
- Ligands
- 35
- Pockets
- 64 · 22 records with a druggable one
Structures
47 records of P9WFK7 in the MolNFT archive: 46 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5EBV | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with… | x-ray diffraction | A | COA, 5LR, CL | — |
| 5EBV | Crystal structure of acetyltransferase eis from mycobacterium tuberculosis in complex with… | x-ray diffraction | A | — | — |
| 5EC4 | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with… | x-ray diffraction | A | COA, 5LQ | — |
| 5EC4 | Crystal structure of acetyltransferase eis from mycobacterium tuberculosis in complex with… | x-ray diffraction | A | — | — |
| 5TVJ | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with CoA and… | x-ray diffraction | A | COA, 7LF, CL | 3 (best 0.78) |
| 5TVJ | Crystal structure of acetyltransferase eis from mycobacterium tuberculosis in complex with CoA and… | x-ray diffraction | A | COA, 7LF, CL | — |
| 6B0U | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a… | x-ray diffraction | A, B, C | COA | 13 (best 0.87) |
| 6B0U | Crystal structure of acetyltransferase eis from mycobacterium tuberculosis in complex with a… | x-ray diffraction | A, B, C | COA | — |
| 6B3T | Crystal structure of acetyltransferase eis from mycobacterium tuberculosis in complex with a… | x-ray diffraction | A | COA, CJ7, NA, SO4 | — |
| 6P3T | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT449 | x-ray diffraction | A | NRS, SO4, NH4 | — |
| 6P3U | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT335 | x-ray diffraction | A | NRY, SO4 | 2 (best 0.77) |
| 6P3U | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT335 | x-ray diffraction | A | NRY, SO4 | — |
| 6P3V | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT416 | x-ray diffraction | A | NRV, SO4 | — |
| 6P3V | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT416 | x-ray diffraction | A | NRV, SO4 | — |
| 6VUR | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT366 | x-ray diffraction | A | ROG, SO4, NA, CL | 3 (best 0.78) |
| 6VUR | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT366 | x-ray diffraction | A | ROG, SO4, NA, CL | — |
| 6VUS | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT379 | x-ray diffraction | A | RNV | 2 (best 0.78) |
| 6VUS | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT379 | x-ray diffraction | A | RNV | — |
| 6VUT | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT392 | x-ray diffraction | A | RN7, SO4, NA | 3 (best 0.77) |
| 6VUT | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT392 | x-ray diffraction | A | RN7, SO4, NA | — |
| 6VUU | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1347 | x-ray diffraction | A | RNJ | 2 (best 0.78) |
| 6VUU | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT1347 | x-ray diffraction | A | RNJ | — |
| 6VUW | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT368 | x-ray diffraction | A | RNM, SO4, NA | 3 (best 0.77) |
| 6VUW | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT368 | x-ray diffraction | A | RNM, SO4, NA | — |
| 6VUX | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT388 | x-ray diffraction | A | H66, SO4, NA | — |
| 6VUY | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT358 | x-ray diffraction | A | RN4, NA, MG | 2 (best 0.80) |
| 6VUY | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT358 | x-ray diffraction | A | RN4, NA, MG | — |
| 6VUZ | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT353 | x-ray diffraction | A | RMS, SO4 | 2 (best 0.77) |
| 6VUZ | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT353 | x-ray diffraction | A | RMS, SO4 | — |
| 6VV0 | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT1354 | x-ray diffraction | A | RMV, SO4 | — |
| 6VV1 | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT384 | x-ray diffraction | A | RMJ, SO4, NA | 2 (best 0.78) |
| 6VV1 | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT384 | x-ray diffraction | A | RMJ, SO4, NA | — |
| 6VV2 | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT1348 | x-ray diffraction | A | RMG, SO4, NA, CL | — |
| 6VV3 | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1358 | x-ray diffraction | A | RM7, SO4, CL | 3 (best 0.77) |
| 6VV3 | Crystal structure of eis from mycobacterium tuberculosis in complex with inhibitor SGT1358 | x-ray diffraction | A | RM7, SO4 | — |
| 6X10 | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with… | x-ray diffraction | A | GMJ, NA, CL | 3 (best 0.77) |
| 6X10 | Crystal structure of acetyltransferase eis from mycobacterium tuberculosis in complex with… | x-ray diffraction | A | GMJ, NA, CL | — |
| 6X6I | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with… | x-ray diffraction | AAA | USG, CL | 2 (best 0.78) |
| 8D1R | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with… | x-ray diffraction | A | PVF | 1 (best 0.78) |
| 8D23 | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with… | x-ray diffraction | A | PVU | 3 (best 0.76) |
| 8D25 | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with… | x-ray diffraction | A | PV3 | 2 (best 0.76) |
| 8F4A | Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with chlorhexidine | x-ray diffraction | A | XC9 | 2 (best 0.77) |
| 8F4U | Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with azelastine | x-ray diffraction | A | XG0, SO4 | 3 (best 0.76) |
| 8F4W | Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with venlafaxine | x-ray diffraction | A | VFX | 3 (best 0.77) |
| 8F4Z | Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with chloroquine | x-ray diffraction | A | CLQ | 2 (best 0.77) |
| 8F57 | Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with inhibitor SGT1615 | x-ray diffraction | A | XEL | 3 (best 0.78) |
| P9WFK7 | AlphaFold monomer V2.0 prediction for N-acetyltransferase eis (P9WFK7) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 22 records
- NA · Sodium ion · in 15 records
- CL · Chloride ion · in 10 records
- COA · Coenzyme A · in 7 records
- 7LF · 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium · in 2 records
- GMJ · 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one · in 2 records
- MG · Magnesium ion · in 2 records
- NRV · N,N-diethyl-2-[(8-fluoro-5-methyl-5H-[1,2,4]triazino[5, 6-b]indol-3-yl)sulfanyl]ethan-1-amine · in 2 records
- NRY · 1-(4-fluorophenyl)-2-[2-(4-fluorophenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium · in 2 records
- RM7 · 2-[(4-amino-6,7,8,9-tetrahydro-5H-cyclohepta[4, 5]thieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(piperidin-1-yl)ethyl]acetamide · in 2 records
- RMJ · 2-[(4-amino-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(piperidin-1-yl) ethyl]acetamide · in 2 records
- RMS · 2-{[3-(piperidin-1-yl)propyl]sulfanyl}-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine · in 2 records
- RN4 · (7S)-7-phenyl-2-{[3-(piperidin-1-yl)propyl]sulfanyl}-5, 6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine · in 2 records
- RN7 · 2-[(4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(morpholin-4-yl) ethyl]acetamide · in 2 records
- RNJ · (7S)-7-methyl-2-{[3-(piperidin-1-yl)propyl]sulfanyl}-7, 8-dihydro[1]benzothieno[2,3-d]pyrimidin-4-amine · in 2 records
- RNM · (7R)-7-methyl-2-({[(3R)-1-methylpiperidin-3-yl]methyl}sulfanyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine · in 2 records
- RNV · 2-[(4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(diethylamino) ethyl]acetamide · in 2 records
- ROG · 2-({[(3S)-1-methylpiperidin-3-yl]methyl}sulfanyl)-5,6, 7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine · in 2 records
- 5LQ · 5-(3-chlorophenyl)-4-methyl-~{N}-(3-morpholin-4-ylpropyl)-1,1-bis(oxidanylidene)-1,2-thiazol-3-amine · in 1 record
- 5LR · 5-(4-chlorophenyl)-~{N}-[3-(3,4-dihydro-1~{H}-isoquinolin-2-yl)propyl]-4-methyl-1,1-bis(oxidanylidene)-1,2-thiazol-3-amine · in 1 record
- CJ7 · 8-fluoro-5-methyl-3-{[2-(piperidin-1-yl) ethyl]sulfanyl}-5H-[1,2,4]triazino[5,6-b]indole · in 1 record
- CLQ · N4-(7-chloro-quinolin-4-yl)-N1,N1-diethyl-pentane-1,4-diamine · in 1 record
- H66 · 2-{[(7S)-4-amino-7-ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-[2-(piperidin-1-yl)ethyl]acetamide · in 1 record
- NH4 · Ammonium ion · in 1 record
- NRS · N-methyl-N-(naphthalen-2-yl)-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide · in 1 record
- PV3 · 1-{2-[(3-chlorophenyl)methoxy]phenyl}-N-[(pyridin-4-yl)methyl]methanamine · in 1 record
- PVF · 1-{3-[(4-chlorophenyl)methoxy]phenyl}methanamine · in 1 record
- PVU · 1-{2-[(3-chlorophenyl)methoxy]phenyl}-N-[(pyridin-3-yl)methyl]methanamine · in 1 record
- RMG · 2-{[3-(piperidin-1-yl)propyl]sulfanyl}-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-amine · in 1 record
- RMV · 2-[(4-amino-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(diethylamino) ethyl]acetamide · in 1 record
Experiment against prediction
- 6VUX chain A against the predicted model P9WFK7: TM-score 1.00, RMSD 0.22 Å
- 6VV2 chain A against the predicted model P9WFK7: TM-score 1.00, RMSD 0.22 Å
- 8F4W chain A against the predicted model P9WFK7: TM-score 1.00, RMSD 0.25 Å
- 6VUS chain A against the predicted model P9WFK7: TM-score 1.00, RMSD 0.27 Å
- 6VUS chain A against the predicted model P9WFK7: TM-score 1.00, RMSD 0.27 Å
- 8F4Z chain A against the predicted model P9WFK7: TM-score 1.00, RMSD 0.27 Å
- 6VUU chain A against the predicted model P9WFK7: TM-score 1.00, RMSD 0.27 Å
- 6VUU chain A against the predicted model P9WFK7: TM-score 1.00, RMSD 0.27 Å
- 6VUY chain A against the predicted model P9WFK7: TM-score 1.00, RMSD 0.28 Å
- 6VUY chain A against the predicted model P9WFK7: TM-score 1.00, RMSD 0.28 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.