UniProt P95493
Gingipain R2 (P95493)
Gingipain R2 (UniProt P95493), EC 3.4.22.37: 10 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P95493
- Protein
- Gingipain R2
- EC
- 3.4.22.37
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 27 · 3 records with a druggable one
Structures
11 records of P95493 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CVR | Crystal structure of the Arg specific cysteine proteinase gingipain R (RGPB) | x-ray diffraction | A | H37, CA, ZN | 1 (best 0.68) |
| 1CVR | Crystal structure of the arg specific cysteine proteinase gingipain R (rgpb) | x-ray diffraction | A | H37, CA, ZN | 1 (best 0.68) |
| 4IEF | Complex of Porphyromonas gingivalis RgpB pro- and mature domains | x-ray diffraction | A, B, C, D, E, F, G, H | CL, BA, CA, NA, MG | 20 (best 0.80) |
| 4IEF | Complex of porphyromonas gingivalis rgpb pro- and mature domains | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5AG8 | Crystal structure of a mutant (665I6H) of the C-terminal domain of rgpb | x-ray diffraction | A, B | SO4 | 2 (best 0.50) |
| 5AG8 | Crystal structure of a mutant (665I6H) of the C-terminal domain of rgpb | x-ray diffraction | A, B | — | — |
| 5AG9 | CRYSTAL STRUCTURE OF A MUTANT (665sXa) C-TERMINAL DOMAIN OF RGPB | x-ray diffraction | A, B | SO4 | 2 (best 0.47) |
| 5AG9 | Crystal structure of a mutant (665SXA) C-terminal domain of rgpb | x-ray diffraction | A, B | — | — |
| 5HFS | Crystal structure of C-terminal domain of cargo proteins of type IX secretion system | x-ray diffraction | A, B | CA, ZN | 1 (best 0.47) |
| 5HFS | Crystal structure of C-terminal domain of cargo proteins of type IX secretion system | x-ray diffraction | A, B | — | — |
| P95493 | AlphaFold monomer V2.0 prediction for gingipain R2 (P95493) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 4 records
- ZN · Zinc ion · in 3 records
- H37 · D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-phenylalaninamide · in 2 records
- SO4 · Sulfate ion · in 2 records
- BA · Barium ion · in 1 record
- CL · Chloride ion · in 1 record
- MG · Magnesium ion · in 1 record
- NA · Sodium ion · in 1 record
Experiment against prediction
- 1CVR chain A against the predicted model P95493: TM-score 0.99, RMSD 0.66 Å
- 1CVR chain A against the predicted model P95493: TM-score 0.99, RMSD 0.66 Å
- 4IEF chain G against the predicted model P95493: TM-score 0.99, RMSD 0.47 Å
- 4IEF chain G against the predicted model P95493: TM-score 0.99, RMSD 0.47 Å
- 4IEF chain B against the predicted model P95493: TM-score 0.99, RMSD 0.96 Å
- 4IEF chain B against the predicted model P95493: TM-score 0.99, RMSD 0.96 Å
- 4IEF chain D against the predicted model P95493: TM-score 0.99, RMSD 0.99 Å
- 4IEF chain D against the predicted model P95493: TM-score 0.99, RMSD 0.99 Å
- 4IEF chain H against the predicted model P95493: TM-score 0.99, RMSD 0.99 Å
- 4IEF chain H against the predicted model P95493: TM-score 0.99, RMSD 0.99 Å
Elsewhere
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