UniProt P83847
Adenine DNA glycosylase (P83847)
Adenine DNA glycosylase (UniProt P83847), EC 3.2.2.-, 3.2.2.31: 23 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P83847
- Protein
- Adenine DNA glycosylase
- EC
- 3.2.2.-, 3.2.2.31
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 28 · 6 records with a druggable one
Structures
24 records of P83847 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1RRQ | MutY adenine glycosylase in complex with DNA containing an A:oxoG pair | x-ray diffraction | A | — | — |
| 1RRQ | Muty adenine glycosylase in complex with DNA containing an A:OXOG pair | x-ray diffraction | A | — | — |
| 1RRS | MutY adenine glycosylase in complex with DNA containing an abasic site | x-ray diffraction | A | — | — |
| 1RRS | Muty adenine glycosylase in complex with DNA containing an abasic site | x-ray diffraction | A | — | — |
| 1VRL | MutY adenine glycosylase in complex with DNA and soaked adenine free base | x-ray diffraction | A | — | — |
| 1VRL | Muty adenine glycosylase in complex with DNA and soaked adenine free base | x-ray diffraction | A | — | — |
| 3G0Q | Crystal Structure of MutY bound to its inhibitor DNA | x-ray diffraction | A | — | — |
| 3G0Q | Crystal structure of muty bound to its inhibitor DNA | x-ray diffraction | A | — | — |
| 4YOQ | Crystal Structure of MutY bound to its anti-substrate | x-ray diffraction | A | — | — |
| 4YOQ | Crystal structure of muty bound to its anti-substrate | x-ray diffraction | A | — | — |
| 4YPH | Crystal Structure of MutY bound to its anti-substrate with the disulfide cross-linker reduced | x-ray diffraction | A | — | — |
| 4YPH | Crystal structure of muty bound to its anti-substrate with the disulfide cross-linker reduced | x-ray diffraction | A | — | — |
| 4YPR | Crystal Structure of D144N MutY bound to its anti-substrate | x-ray diffraction | A, B | — | — |
| 4YPR | Crystal structure of D144N muty bound to its anti-substrate | x-ray diffraction | A, B | — | — |
| 5KN8 | MutY N-terminal domain in complex with undamaged DNA | x-ray diffraction | A | SF4, CA | 3 (best 0.69) |
| 5KN8 | Muty N-terminal domain in complex with undamaged DNA | x-ray diffraction | A | SF4, CA | — |
| 5KN9 | MutY N-terminal domain in complex with DNA containing an intrahelical oxoG:A base-pair | x-ray diffraction | A | SF4, CA | 3 (best 0.71) |
| 5KN9 | Muty N-terminal domain in complex with DNA containing an intrahelical OXOG:A base-pair | x-ray diffraction | A | SF4, CA | — |
| 6Q0C | Muty adenine glycosylase bound to DNA containing a transition state analog (1N) paired with… | x-ray diffraction | A | SF4, CA | — |
| 6U7T | Muty adenine glycosylase bound to DNA containing a transition state analog (1N) paired with… | x-ray diffraction | A | SF4, CA | — |
| 8DWD | Adenine glycosylase MutY variant E43S in complex with DNA containing d(8-oxo-G) paired with an AP… | x-ray diffraction | A | SF4, CA | 4 (best 0.77) |
| 8DWE | Adenine glycosylase MutY variant E43Q in complex with DNA containing d(8-oxo-G) paired with… | x-ray diffraction | A, D | SF4, CA | 9 (best 0.73) |
| 8DWF | Glycosylase MutY variant E43S in complex with DNA containing d(8-oxo-G) paired with substrate… | x-ray diffraction | A, D | SF4, CA | 7 (best 0.71) |
| P83847 | AlphaFold monomer V2.0 prediction for adenine DNA glycosylase (P83847) | predicted | A | — | 2 (best 0.58) |
Ligands
Experiment against prediction
- 8DWD chain A against the predicted model P83847: TM-score 0.99, RMSD 0.52 Å
- 6U7T chain A against the predicted model P83847: TM-score 0.99, RMSD 0.54 Å
- 6Q0C chain A against the predicted model P83847: TM-score 0.99, RMSD 0.55 Å
- 4YPR chain B against the predicted model P83847: TM-score 0.99, RMSD 0.57 Å
- 4YPR chain B against the predicted model P83847: TM-score 0.99, RMSD 0.57 Å
- 1VRL chain A against the predicted model P83847: TM-score 0.99, RMSD 0.60 Å
- 1VRL chain A against the predicted model P83847: TM-score 0.99, RMSD 0.60 Å
- 8DWF chain D against the predicted model P83847: TM-score 0.99, RMSD 0.62 Å
- 1RRS chain A against the predicted model P83847: TM-score 0.99, RMSD 0.67 Å
- 1RRS chain A against the predicted model P83847: TM-score 0.99, RMSD 0.67 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.