UniProt P83476
Beta/omega-theraphotoxin-Tp2a (P83476)
Beta/omega-theraphotoxin-Tp2a (UniProt P83476): 12 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P83476
- Protein
- Beta/omega-theraphotoxin-Tp2a
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 20 · 4 records with a druggable one
Structures
13 records of P83476 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2N9T | NMR solution structure of ProTx-II | solution nmr | A | — | — |
| 2N9T | NMR solution structure of protx-II | solution nmr | A | — | — |
| 5O0U | Crystal structure of tarantula venom peptide Protoxin-II | x-ray diffraction | A | CL | — |
| 5O0U | Crystal structure of tarantula venom peptide protoxin-II | x-ray diffraction | A | CL | — |
| 6MK4 | Solution NMR structure of spider toxin analogue [E17K]ProTx-II | solution nmr | A | — | — |
| 6MK4 | Solution NMR structure of spider toxin analogue [E17K]PROTX-II | solution nmr | A | — | — |
| 6N4I | Structural basis of Nav1.7 inhibition by a gating-modifier spider toxin | x-ray diffraction | E, F, G, H | 6OU | 2 (best 0.48) |
| 6N4I | Structural basis of NAV1.7 inhibition by a gating-modifier spider toxin | x-ray diffraction | E, F, G, H | 6OU | 2 (best 0.48) |
| 6N4Q | CryoEM structure of Nav1.7 VSD2 (actived state) in complex with the gating modifier toxin ProTx2 | electron microscopy | E, F, G, H | — | 4 (best 0.78) |
| 6N4Q | Cryoem structure of NAV1.7 VSD2 (actived state) in complex with the gating modifier toxin PROTX2 | electron microscopy | E, F, G, H | — | 4 (best 0.78) |
| 6N4R | CryoEM structure of Nav1.7 VSD2 (deactived state) in complex with the gating modifier toxin ProTx2 | electron microscopy | E, F, G, H | — | 4 (best 0.73) |
| 6N4R | Cryoem structure of NAV1.7 VSD2 (deactived state) in complex with the gating modifier toxin PROTX2 | electron microscopy | E, F, G, H | — | 4 (best 0.73) |
| P83476 | AlphaFold monomer V2.0 prediction for BETA/OMEGA-theraphotoxin-TP2A (P83476) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5O0U chain A against the predicted model P83476: TM-score 0.87, RMSD 0.83 Å
- 5O0U chain A against the predicted model P83476: TM-score 0.87, RMSD 0.83 Å
- 6N4I chain E against the predicted model P83476: TM-score 0.86, RMSD 1.05 Å
- 6N4I chain E against the predicted model P83476: TM-score 0.86, RMSD 1.05 Å
- 6N4R chain E against the predicted model P83476: TM-score 0.76, RMSD 0.95 Å
- 6N4R chain E against the predicted model P83476: TM-score 0.76, RMSD 0.95 Å
- 6N4Q chain E against the predicted model P83476: TM-score 0.76, RMSD 1.35 Å
- 6N4Q chain E against the predicted model P83476: TM-score 0.76, RMSD 1.35 Å
- 6MK4 chain A against the predicted model P83476: TM-score 0.75, RMSD 0.94 Å
- 6MK4 chain A against the predicted model P83476: TM-score 0.75, RMSD 0.94 Å
Elsewhere
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