UniProt P80884
Ananain (P80884)
Ananain (UniProt P80884), EC 3.4.22.31: 12 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 38 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P80884
- Protein
- Ananain
- EC
- 3.4.22.31
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 38 · 12 records with a druggable one
Structures
13 records of P80884 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6MIS | Native ananain in complex with E-64 | x-ray diffraction | A, B | E64 | 3 (best 0.64) |
| 6MIS | Native ananain in complex with E-64 | x-ray diffraction | A, B | E64 | 3 (best 0.64) |
| 6OKJ | Native ananain from Ananas comosus | x-ray diffraction | A, B | — | 4 (best 0.53) |
| 6OKJ | Native ananain from ananas comosus | x-ray diffraction | A, B | — | 4 (best 0.53) |
| 6Y6L | Structure the ananain protease from Ananas comosus with a thiomethylated catalytic cysteine | x-ray diffraction | A, B | SO4 | 3 (best 0.57) |
| 6Y6L | Structure the ananain protease from ananas comosus with a thiomethylated catalytic cysteine | x-ray diffraction | A, B | SO4 | 3 (best 0.57) |
| 6YCB | Structure the ananain protease from Ananas comosus covalently bound to with the E64 inhibitor | x-ray diffraction | A, B | SO4 | 3 (best 0.53) |
| 6YCB | Structure the ananain protease from ananas comosus covalently bound to with the E64 inhibitor | x-ray diffraction | A, B | SO4 | 3 (best 0.53) |
| 6YCC | Structure the ananain protease from Ananas comosus covalently bound to the E64 inhibitor | x-ray diffraction | A, B | E64, SO4 | 3 (best 0.54) |
| 6YCC | Structure the ananain protease from ananas comosus covalently bound to the E64 inhibitor | x-ray diffraction | A, B | E64, SO4 | 3 (best 0.54) |
| 6YCD | Structure the ananain protease from Ananas comosus covalently bound to the TLCK inhibitor | x-ray diffraction | A, B | TCK, SO4 | 3 (best 0.57) |
| 6YCD | Structure the ananain protease from ananas comosus covalently bound to the tlck inhibitor | x-ray diffraction | A, B | TCK, SO4 | 3 (best 0.57) |
| P80884 | AlphaFold monomer V2.0 prediction for ananain (P80884) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6YCC chain A against the predicted model P80884: TM-score 0.99, RMSD 0.42 Å
- 6YCC chain A against the predicted model P80884: TM-score 0.99, RMSD 0.42 Å
- 6YCD chain A against the predicted model P80884: TM-score 0.99, RMSD 0.43 Å
- 6YCD chain A against the predicted model P80884: TM-score 0.99, RMSD 0.43 Å
- 6YCD chain B against the predicted model P80884: TM-score 0.99, RMSD 0.45 Å
- 6YCD chain B against the predicted model P80884: TM-score 0.99, RMSD 0.45 Å
- 6YCB chain A against the predicted model P80884: TM-score 0.99, RMSD 0.46 Å
- 6YCB chain A against the predicted model P80884: TM-score 0.99, RMSD 0.46 Å
- 6Y6L chain A against the predicted model P80884: TM-score 0.99, RMSD 0.47 Å
- 6Y6L chain A against the predicted model P80884: TM-score 0.99, RMSD 0.47 Å
Elsewhere
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