UniProt P80186
Tetrahydromethanopterin S-methyltransferase subunit E (P80186)
Tetrahydromethanopterin S-methyltransferase subunit E (UniProt P80186): 2 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P80186
- Protein
- Tetrahydromethanopterin S-methyltransferase subunit E
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 35 · 2 records with a druggable one
Structures
3 records of P80186 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8Q3V | Cryo-EM structure of the methanogenic Na+ translocating N5-methyl-H4MPT:CoM methyltransferase… | electron microscopy | E, e, U | JCV, NA | 18 (best 0.86) |
| 8Q54 | N5-methyl-H4MPT:CoM methyltransferase -coenzyme M complex + CoM | electron microscopy | E, e, U | JCV, NA, COM | 17 (best 0.86) |
| P80186 | AlphaFold monomer V2.0 prediction for tetrahydromethanopterin S-methyltransferase subunit E (P80186) | predicted | A | — | — |
Ligands
- JCV · [(2~{S},7~{R},11~{R},15~{S},19~{S},22~{S},26~{S},30~{R},34~{R},39~{S},43~{R},47~{R},51~{S},55~{S},58~{S},62~{S},66~{R},70~{R})-39-[[(2~{R},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxymethyl]-7,11,15,19,22,26,30,34,43,47,51,55,58,62,66,70-hexadecamethyl-1,4,37,40-tetraoxacyclodoheptacont-2-yl]methyl [(2~{R},3~{S},5~{R},6~{R})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl] hydrogen phosphate · in 2 records
- NA · Sodium ion · in 2 records
- COM · 1-thioethanesulfonic acid · in 1 record
Experiment against prediction
- 8Q3V chain U against the predicted model P80186: TM-score 0.96, RMSD 1.50 Å
- 8Q54 chain E against the predicted model P80186: TM-score 0.96, RMSD 1.51 Å
- 8Q3V chain E against the predicted model P80186: TM-score 0.96, RMSD 1.51 Å
- 8Q3V chain e against the predicted model P80186: TM-score 0.96, RMSD 1.51 Å
- 8Q54 chain e against the predicted model P80186: TM-score 0.96, RMSD 1.52 Å
- 8Q54 chain U against the predicted model P80186: TM-score 0.96, RMSD 1.52 Å
Elsewhere
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